摘要
川芎作为祖国传统中药材,素因其有效的化学成分及广泛的药理作用而闻名于世。川芎所含有的多种化学成分分别在抗炎、镇痛、抗血栓形成、促血管舒张、抗哮喘、抗呼吸抑制、抗纤维化、抗阻塞性疾病及抗肿瘤等方面产生了积极的影响。在这些有效成分中,以苯酞类化合物、川芎嗪以及阿魏酸的作用最为广泛且效力更强,洋川芎内酯以及藁本内酯等亦发挥了积极地作用。目前,研究者们对川芎中有效化学成分在临床应用中的作用机制的研究尚未深入,其所具有的药理作用亦需要更进一步的探究。本文对川芎的化学成分及其药理作用的研究新进展进行综述与总结,以期为今后更进一步探索川芎的药用前景提供科学依据及理论参考。
As a traditional Chinese medicine,chuanxiong is famous for its effective chemical components and extensive pharmacological effects.The chemical components of ligusticum chuanxiong have positive effects on anti-inflammation,analgesia,anti-thrombosis,vasodilation,anti-asthma,anti-respiratory inhibition,anti-fibrosis,anti-obstructive disease and anti-tumor.Among these active constituents,phthalide,ligustrazine and ferulic acid have the most extensive and stronger effects.Ligustilide and ligustilide also play an active role.At present,researchers have not studied the mechanism of action of effective chemical components in ligusticum chuanxiong in clinical application,and their pharmacological effects need further exploration.In order to provide scientific basis and theoretical reference for further exploration of the medicinal prospect of ligusticum chuanxiong,this paper summarizes the recent progress in the research on the chemical constituents and pharmacological effects of ligusticum chuanxiong.
作者
李芊
吴效科
LI Qian;WU Xiao-ke(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
出处
《化学工程师》
CAS
2020年第1期62-64,44,共4页
Chemical Engineer
基金
黑龙江省“头雁”团队支持资金([2019]9号)
国家重大科技专项-公益性中医行业专项(No.201507001-02)
国家重大疑难疾病中西医临床协作试点项目-国中医药办医政发([2018]3号).
关键词
川芎
化学成分
药理作用
妇科疾病
研究进展
Ligusticum chuanxiong Hort
chemical composition
pharmacological action
gynecological diseases
the research progress
作者简介
李芊(1989-),女,哈尔滨人,黑龙江中医药大学2017级中医妇科学在读博士研究生;通信作者:吴效科(1966-),男,博士,博士研究生导师,黑龙江中医药大学附属第一医院妇科一科主任,主任医师,毕业于南京医科大学妇产科,研究方向:中西医结合治疗不孕症。
