摘要
黄连Coptidis Rhizoma是我国常用的大宗中药材,资源丰富,具有广阔的开发利用前景。黄连化学成分类型丰富,主要为生物碱、苯丙素、黄酮、挥发油等。在黄连化学成分、药理作用综述的基础上,根据中药质量标志物(Quality marker, Q-Marker)的概念,从化学可测性、植物亲缘学、炮制方法、配伍应用、传统药性、主要功效和网络药理学的方面进行预测分析,大类成分以生物碱、酚性成分、挥发油和木脂素为质量标志物,以小檗碱、黄连碱、巴马汀、小檗红碱、药根碱、非洲防己碱、表小檗碱、格兰地新、阿魏酸、绿原酸等单一成分为备选物质,为明确黄连Q-Marker和制定科学的质量标准提供一定的参考。
Huanglian(Coptidis Rhizoma) is a commonly used substantial Chinese medicinal material in China, with rich resources and wide distribution, and has broad prospects for development and utilization. Huanglian(Coptidis Rhizoma) is rich in chemical components, mainly including alkaloids, phenylpropanin, flavonoids, volatile oils, etc. On the basis of the review of the chemical composition and pharmacological effect of Huanglian(Coptidis Rhizoma),according to the concept of quality markers(Q-Marker), the Q-Marker components of Huanglian(Coptidis Rhizoma) were predicted and analyzed from the aspects of chemical composition, plant affinity, traditional medicinal properties and efficacy, pharmacological effects, preparation methods, drug pairing and network pharmacology. Alkaloids, phenolic components, volatile oils and lignans are the quality markers, and berberine, coptisine, palmatine, berberrubine, jatrorrhizine, groenlandicine, columbamine, epiberberine, ferulic acid, chlorogenic acid and other single components are the candidate substances, providing a reference for clarifying the Q-Marker of Huanglian(Coptidis Rhizoma) and formulating the scientific quality standards.
作者
蒋丽施
李潇彧
罗曦
何昊奇
顾玲
陶彦伶
苟莎
邓赟
JIANG Lishi;LI Xiaoyu;LUO Xi;HE Haoqi;GU Ling;TAO Yanling;COU Sha;DENG Yun(College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611100,Sichuan,China;School of Public Health,Chengdu University of Traditional Chinese Medicine,Chengdu 611100,Sichuan,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第8期97-109,共13页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金联合基金项目(U19A200061)
成都中医药大学一流学科建设项目(CZYJC1905)
成都中医药大学“杏林人才提升计划”项目(ZRQN2020029)。
关键词
黄连
生物碱
质量标志物
化学成分
药理作用
Huanglian(Coptidis Rhizoma)
alkaloids
quality markers
chemical constituents
pharmacological effects
作者简介
蒋丽施(1986-),女,四川简阳人,讲师,博士在读,研究方向:天然活性成分的开发与利用;通讯作者:邓赟(1975-),男,四川绵阳人,研究员,博士研究生导师,研究方向:中药药效物质基础。E-mail:dengyun2000@hotmail.com。
