摘要
基于中医传承辅助平台软件,分析中国期刊全文数据库(CNKI)、万方数据知识服务平台、维普网、中国生物医学文献数据库(CBM)中以中医药治疗抑郁症的组方用药规律,为进一步挖掘中医药治疗抑郁症及新药研发提供参考。应用中医传承辅助平台软件V2.0,构建中医药治疗抑郁症的方剂数据库,采用软件集成的数据挖掘方法,对方剂数据库进行四气、五味、归经分布及频次统计、证型分布、组方规律、新方分析。通过对治疗抑郁症的358首方剂分析,确定了处方中药物出现的频次、常用药对及组合,演化得到新处方22首。研究表明,现代文献数据库中收录治疗抑郁症的方剂以疏肝解郁、健脾化痰、活血补血、疏肝理气、健脾益气、清热泻火、开窍醒神、安神定志、滋阴补肾等功效为主,药性多偏于温平,药味苦甘辛,体现了抑郁症"理气开郁,调畅气机,移情易性"的治疗原则。
To analyze the prescription and medication regularities of traditional Chinese medicines in the treatment of melancholia in the Chinese journal full text database （ CNKI）, Wanfang Data knowledge service platform, VIP, Chinese biomedical literature database （CBM） in based on the traditional Chinese medicine inheritance support platform software, in order to provide reference for further mining traditional Chinese medicines for the treatment of melancholia and new drug development. The traditional Chinese medicine inheritance support platform software V2. 0 was used to establish the prescription database of traditional Chinese medicines for treating melancholia. The software integrated data mining method was adopted to analyze four Qis, five flavors, meridian distribution, frequency statistics, syndrome distribution, composition regularity and new prescriptions. Totally 358 prescriptions for treating melancholia were analyzed to determine the frequency of prescription drugs, commonly used drug pairs and combinations and develop 22 new prescriptions. According to this study, prescriptions for treating depression collected in modern literature databases mainly have the effects in soothing liver and resolving melancholia, strengthening spleen and eliminating phlegm, activating and replenishing blood, regulating liver qi, tonifying spleen qi, clearing heat and purging heat, soothing the mind, nourishing yin and tonifying kidney, with neutral drug property and sweet or bitter flavor, and follow the melancholia treatment principle of ＂regulating qi and opening the mind, regulating qi and empathy＂.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第10期2042-2046,共5页
China Journal of Chinese Materia Medica
基金
山东省科技发展计划项目(2014GSF119010)
山东省中医药科技发展计划项目(2013ZDZK-010)
关键词
数据挖掘
抑郁症
中医传承辅助平台
方剂
组方规律
data mining
melancholia
traditional Chinese medicine inheritance support platform
prescription
composition principles of prescriptions and drug laws
作者简介
赵艳青，硕士研究生，Tel：15964532621，E—mail：zhaoyanqing1983@126．com
[通信作者]滕晶，副教授，博士后，Tel：13573175851，E—mail：tengjing1972@163．com
