摘要
综述PI3K-AKT信号通路与抑郁症的关系及中医干预作用研究进展。研究发现,抑郁症的发病机制与PI3K-AKT信号通路密切相关,通过促进PI3K-AKT信号通路激活,能够改善突触可塑性,进而对抑郁行为的改善起促进作用。针灸、中药、方剂对抑郁症有一定的疗效,通过促进PI3K-AKT激活改善突触可塑性是其改善抑郁状态的作用机制之一。
The relationship between PI3K-AKT signaling pathway and the research progress on depression and the effect of TCM intervention was reviewed.It was found that the pathogenesis of depression is closely related to PI3K-AKT signaling pathway.By promoting the activation of PI3K-AKT signaling pathway,synaptic plasticity can be improved to facilitate the improvement of depression behaviors.Acupuncture,traditional Chinese medicine and formulas have a certain effect on the treatment of depression with the mechanism of improving synaptic plasticity via the activation of PI3K-Akt signaling pathway.
作者
黄芸
张治楠
黄泳
曲姗姗
钟正
HUANG Yun;ZHANG Zhinan;HUANG Yong;QU Shanshan;ZHONG Zheng(The First Clinical Medicine School,Southern Medical University,Guangzhou 510515,Guangdong,China;School of traditional Chinese Medicine of Southern Medical University,Guangzhou 510515,Guangdong,China;Dept.of Traditional Chinese Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China)
出处
《上海中医药杂志》
2020年第2期108-112,共5页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81873359,81603474)
广东省科学技术厅自然科学基金项目(2016A030313522,2016A030310383)
广东省科学技术厅科技计划项目(2013A032500001)
广东省广州市科技创新委员会科技计划项目(201707010041)
广东省中医药局第二批中医临床优秀人才研修项目[粤中医办(2017-267)]
南方医院2018年度院长基金项目(2018Z023).
关键词
抑郁症
PI3K-AKT
突触可塑性
针灸
中药
方剂
综述
depression
PI3K-AKT
synaptic plasticity
acupuncture
traditional Chinese medicine
formulas
review
作者简介
黄芸,女,硕士研究生,主要从事针灸效应机制研究工作;通讯作者:黄泳,教授,主任医师。E-mail:nfhy@smu.edu.cn
