摘要
应用系统平台收集、整理《中医方剂大辞典》中治疗胃火炽盛型消渴病的方剂,将符合条件的103首方剂录入系统平台,并利用Apriori算法对所选方剂进行用药规律分析。对筛选出的方剂进行分析,得到使用频次>8的药物29种。Apriori算法用药规律分析得到33个常用药对(支持度≥10),23个3味药物核心组合(支持度≥8),21个4味药物核心组合(支持度≥4)。对治疗胃火炽盛型消渴病方剂中药物关联规则进行分析(支持度个数≥10,置信度≥0.5),得出关联度最高的药物组合。对治疗胃火炽盛型消渴病方剂中药物性味、归经和药量进行分析,得出药物性味、归经和药量频次。通过对以上数据的分析和总结得出,天花粉、知母、黄连、麦冬4味药物的组合、用量以及用量比例,体现出针对胃火炽盛型消渴病以清泻胃火为主,同时兼顾滋补肺、肾等脏腑之阴的治疗理念,既针对胃火炽盛型消渴病之临床表现,又符合胃火炽盛型消渴病"火盛水亏"之病机,在一定程度上反映了中医治疗胃火炽盛型消渴病的用药规律,对临床组方用药具有重要的指导价值。
To analyze the medication regularity of traditional Chinese medicine(TCM)prescriptions for gastropyretic excessiveness diabetes recorded in Chinese Medicine Prescriptions Dictionary.A total of 103 eligible prescriptions were input into the system platform,and the Apriori algorithm was used to analyze their medication regularity.The 103 prescriptions for gastropyretic excessiveness diabetes were selected from the system,and 29 herb medicines were found with frequency of usage more than 8.Totally 33 commonly used herbal pairs(support degree≥10),twenty-three 3-herb core combinations(support degree≥8,confidence values≥0.5),and twenty-one 4-herb core combinations(confidence values≥0.5)were discovered after the medication regularity analysis by Apriori algorithm.The herbal medicine combinations with the highest correlation degree were discovered after the association rule analysis on the 103 prescriptions(support degree≥10,confidence values≥0.5).The four properties,five tastes,channel distributions and frequency of dose of the 103 prescriptions were also obtained after the corresponding analysis.According to the analysis and summary of the above data,the combination of Trichosanthis Radix,Anemarrhenae Rhizoma,Coptidis Rhizoma and Ophiopogonis Radix could reflect the medication regularity of TCM prescriptions for gastropyretic excessiveness diabetes to a certain degree,which is of great significance in guiding value in clinic.
作者
王烨燃
张洋
秦琦冰
王萍
谭龙
WANG Ye-ran;ZHANG Yang;QIN Qi-bing;WANG Ping;TAN Long(Heilongjiang University of Chinese Medicine,Harbin 150040,China;National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Heilongjiang University,Harbin 150000,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第1期196-201,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(81273649,81774201).
关键词
《中医方剂大辞典》
胃火炽盛
消渴病
系统平台
用药规律
Chinese Medicine Prescriptions Dictionary
gastropyretic excessiveness
diabetes
system platform
medication regularity
作者简介
王烨燃,E-mail:15195116@qq.com;通信作者:王萍,研究员,主要从事中药血清药物化学、中医方证代谢组学及心脑血管疾病发病机制研究,E-mail:hudielanwp@sina.com;通信作者:谭龙,副教授,主要从事计算机数据挖掘技术研究,E-mail:tanlong@hlju.edu.cn
