摘要
针灸技术在中医临床中起着重要的作用,针灸治疗神经内科疾病具有明显的优势,李志刚教授在长期临床实践和科研的基础上总结出"通督启神"法电针治疗阿尔茨海默病(Alzheimer disease,AD),坚持以"通督"为手段,以"启神"为目的,通过实验室研究证明其可在一定程度改善AD模型实验动物的学习和记忆能力,近年来本课题组从脑部海马神经元保护、PI3K/Akt信号、星形胶质细胞、小胶质细胞活化、海马脑血流量等方面进行机制研究,取得了显著的科研成果,本文旨在对近年来本团队用"通督启神"法电针治疗AD模型小鼠的作用机制进行简要阐述。
Acupuncture plays an important role in the clinical practice of traditional Chinese medicine.Acupuncture has obvious advantages in the treatment of neurological diseases.Professor Li Zhigang summed up the method of"Tong Du Qi Shen"to treat Alzheimer’s disease on the basis of long-term clinical practice and scientific research.He insisted on taking"Tong Du"as the means and"Qi Shen"as the purpose,which can be proved in a certain degree through laboratory research To improve the learning and memory ability of AD model experimental animals,in recent years,our team made remarkable scientific research results from the aspects of brain hippocampal neuron protection,PI3 K/Akt signal,microglia activation,hippocampal cerebral blood flow and so on.The purpose of this paper is to briefly explain the mechanism of our team’s"Tong Du Qi Shen"acupuncture treatment of AD model mice in recent years Narrated.
作者
孙润权
王鑫
牟秋杰
田会玲
王顺
李志刚
Sun Runquan;Wang Xin;Mou Qiujie;Tian Huiling;Wang Shun;Li Zhigang(School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China;Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University,Beijing 10010,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第8期2647-2651,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81973938):基于miRNAs介导的小胶质细胞极化途径探讨“通督启神”针法治疗AD的机制研究,负责人:李志刚
国家自然科学基金委员会青年科学基金项目(81804178):从TREM2甲基化水平探讨针刺干预AD的作用机制,负责人:姜婧
国家自然科学基金青年科学基金项目(81904277):基于Parkin活化探讨“通督启神”法电针调控线粒体自噬干预AD小鼠的脑保护机制,负责人:王鑫
关键词
通督启神
阿尔茨海默病
机制研究
针刺
Tong Du Qi Shen
Alzheimer’s disease
Mechanism
Acupuncture
作者简介
通讯作者:李志刚,教授,博士生导师,主要研究方向:针刺手法及针刺干预中枢神经损伤机理的研究。
