摘要
阿尔茨海默病(Alzheimer’s disease,AD)属于多因素、多机制类疾病,已对人类健康造成了严重的威胁。针灸作为传统医学的重要组成部分,具有多靶点、多途径和多层面的作用特点。本文对近年来国内外有关针灸治疗AD的研究进行了回顾,发现针灸可通过调控脑内蛋白质的异常表达、调控小胶质细胞的生理病理状态、调控线粒体自噬、调控表观遗传修饰、发挥神经元保护效应、改善突触可塑性、调控氧化应激反应和调控能量代谢等多种途径发挥对AD的整体调控效应。深入探析针灸治疗AD的效应机制,揭示其深层作用原理,以期为AD的临床诊断和治疗提供科学合理的理论依据。
Alzheimer’s disease(AD)is a multi-factor and multi-mechanism disease,which has posed a serious threat to human health.As an important part of traditional medicine,acupuncture has the characteristics of multi-target,multipathway and multi-layer.This paper reviews the studies on acupuncture and moxibustion in the treatment of AD in China and overseas in recent years,and finds that acupuncture can treat AD in the following ways:Regulating the abnormal expression of proteins in the brain;Regulating the physiological and pathological state of microglia;Regulating mitochondrial autophagy;Regulating epigenetic modification;Protecting neurons;Improving synaptic plasticity;Regulating oxidative stress response;Regulating energy metabolism.An in-depth analysis of the effect mechanism of acupuncture and moxibustion on AD can provide a scientific and reasonable theoretical basis for the clinical diagnosis and treatment of AD.
作者
牟秋杰
姜婧
王鑫
李昱颉
田会玲
王顺
嵇波
李志刚
Mou Qiujie;Jiang Jing;Wang Xin;Li Yujie;Tian Huiling;Wang Shun;Ji Bo;Li Zhigang(School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China;School of Nursing,Beijing University of Chinese Medicine,Beijing 100029,China;Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第8期2621-2627,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81973938):基于miRNAs介导的小胶质细胞极化途径探讨“通督启神”针法治疗AD的机制研究,负责人:李志刚
国家自然科学基金委员会青年科学基金项目(81804178):从TREM2甲基化水平探讨针刺干预AD的作用机制,负责人:姜婧
国家自然科学基金委员会青年科学基金项目(81904277):基于Parkin活化探讨“通督启神”法电针调控线粒体自噬干预AD小鼠的脑保护机制,负责人:王鑫
关键词
阿尔茨海默病
保护机制
线粒体自噬
表观遗传
针灸
综述
Alzheimer’s disease
Protection mechanism
Mitochondrial autophagy
Epigenetic inheritance
Acupuncture and moxibustion
Review
作者简介
通讯作者:李志刚,教授,博士生导师,主要研究方向:针刺手法及针刺干预中枢神经损伤的机理研究;通讯作者:嵇波,教授,博士生导师,主要研究方向:针灸作用规律与机理研究。
