摘要
快速老化小鼠是一种早期学习记忆障碍模型,因其表现出阿尔茨海默病发病机制的大多数特征,包括抗衰老因子的异常表达、炎症因子的过度升高、淀粉样蛋白沉积、tau蛋白过度磷酸化、线粒体自噬、血脑屏障损伤的中枢机制以及多系统多器官的病理损伤,因而成为阿尔茨海默病(Alzheimer's disease,AD)研究的理想模型而广泛应用。随着AD机制实验研究的不断深入,发现SAMP8小鼠在行为活动、组织病理及生化参数指标上相较于SAMR1发生明显变化,并与人体疾病相类似。基于此,本文对SAMP8小鼠的行为学、组织病理和中医药实验研究进行了系统综述,加深对SAMP8小鼠的认识,了解其生理病理特性,并依据中医药实验研究对其中医证型进行推测,以期对SAMP8小鼠的科学应用提供有益帮助。
The senescence accelerate mouse prone are a model of early learning and memory impairment,because they exhibit most of the characteristics of the pathogenesis of Alzheimer′s disease,including abnormal expression of antiaging factors,excessive increase of inflammatory factors,amyloid deposition,tau protein hyperphosphorylation,mitochondrial autophagy,the central mechanism of blood-brain barrier damage,and pathological damage of multiple systems and organs.Therefore,it has been widely used as an ideal model for Alzheimer′s disease research.With the deepening of the experimental research on the mechanism of AD,it was found that SAMP8 mice showed obvious changes in behavior,histopathology and biochemical parameters compared with SAMR1,which were similar to human diseases.Therefore,this paper reviews the research progress of SAMP8 mice in recent years,in order to provide useful guidance and help for the application of SAMP8 mouse model in a variety of aging diseases.
作者
吴国庆
高誉珊
汪子栋
李志刚
WU Guoqing;GAO Yushan;WANG Zidong;LI Zhigang(College of Acupuncture and Massage,Beijing University of Chinese Medicine,Beijing 100029,China;College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2024年第4期886-894,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81973938):基于miRNA介导的小胶质细胞级化途径探讨“通督启神”针法治疗AD的机制研究,负责人:李志刚
国家自然科学基金委员会面上项目(82274654):中性粒细胞粘附与内皮修复途径探讨“通督启神”针法干预AD的血脑屏障保护机制研究,负责人:李志刚
北京中医药大学揭榜挂帅项目(2022-JYB-JBZR-024):穴位敏化物质基础与成象研究,负责人:李志刚
关键词
快速老化小鼠
行为学
病理变化
阿尔茨海默病
综述
Senescence accelerate mouse prone
Behavioral
Pathological changes
Alzheimer′s disease
Review
作者简介
通讯作者:李志刚,本刊副主编,博士生导师,教授,主要研究方向:针刺手法及针刺干预中枢神经损伤机理的研究。
