摘要
中药经典名方开发已成为当下中医药界研究的热点之一,而其中经典名方物质基准的成功研制对于整个中药经典名方的申报极为关键。经典名方物质基准既是检测经典名方制剂质量的基准,同时又需反映整方的物质基础。中药成分众多而复杂,单成分的、化药式的研发与质量控制模式难以适用于整体药用的中药制剂的开发,亟需开辟一条中药专属的研发模式。以目前已有的现代科学技术,笔者建议将中药的遗传多态性、提取动力学、指纹图谱总量统计矩(相似度)法、超分子'印迹模板'等结合应用于经典名方物质基准的研制,探讨中药经典名方物质基准的质量控制技术,以期全面、准确地阐明药材-饮片-物质基准的成分群量值的传递规律,为推进中药经典名方的研制进程提供参考。
Research and development of classical prescription of Chinese medicine has become one of the hot spots in the research of traditional Chinese medicine(TCM),and the successful development of the primary standard is crucial to the application of the classical prescription of Chinese medicine.Primary standard of classical prescription is not only the benchmark to measure the quality of preparation of classical prescription,but also the material basis of whole prescription.The development and quality control mode of single component of western medicine is not suitable for the development of TCM preparation with integral medicinal function.Thus,it is very urgent to develop an exclusive research and development model for TCM.In order to break through the quality control technology of primary standard of classical prescription,and comprehensively and accurately elucidate the transmission rule of the component group value of medicinal materials-decoction pieces-primary standard of classical prescription with the present modern science and technology,the genetic polymorphism of TCM,extraction kinetics,total quantum statistical moment(similarity)method of fingerprint and supramolecular imprinting template were combined and applied to the development of primary standard of classical prescription.In this way,the development and quality control of TCM will be realized in a real sense and the development of classical prescription of Chinese medicine will be accelerated and promoted.
作者
樊启猛
贺鹏
李海英
刘润南
贺玉婷
梁慧慧
刘文龙
周逸群
贺福元
FAN Qi-meng;HE Peng;LI Hai-ying;LIU Run-nan;HE Yu-ting;LIANG Hui-hui;LIU Wen-long;ZHOU Yi-qun;HE Fu-yuan(College of Pharmacy,Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine,Pharmaceutical Preparation Technology and Evaluation Laboratory of Modern Chinese Medicine,Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica,Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2019年第15期202-209,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81573691,81703824,81803729,81874507)
湖南省自然科学基金项目(2016JJ4065,2019JJ50430)
湖南中医药大学研究生科研创新课题(2018CX18,CX2018B504)
湖南省教育厅创新平台开放基金项目(18K071)
关键词
中药
经典名方
物质基准
关键技术
总量统计矩
超分子“印迹模板”
指纹图谱
Chinese medicine
classical prescription
primary standard
key technologies
total quantum statistical moment
supramolecular imprinting template
fingerprint
作者简介
第一作者:樊启猛,在读博士,从事中药药理学、中药药剂学、中医药超分子与数理特征化研究,Tel:0731-85381372,E-mail:qimengfan1989@qq.com;通信作者:周逸群,硕士,讲师,从事中药炮制、饮片质量标准、中医药超分子的研究,Tel:0731-85381372,E-mail:zhouyiqun123@sina.com;通信作者:贺福元,博士,教授,从事中药药理学、中药药剂学、中医药超分子与数理特征化的研究,Tel:0731-85381372,E-mail:pharmsharking@tom.com
