摘要
有毒中药毒性复杂,常通过配伍的方式达到减毒的目的,但配伍后的毒性改变尚未清楚,因此有毒中药配伍后的毒性评估至关重要,是临床用药前的重要环节。代谢组学在评估药物毒性方面具有显著的优势,但目前缺乏配伍减毒后毒性评估的系统性论述,故笔者梳理了近年来代谢组学运用于有毒中药配伍减毒中的相关文献。笔者从代谢组学的概况及代谢组学在含有毒中药药对、复方中展开论述,比较配伍前后的毒性生物标志物和代谢通路,将代谢过程中发生变化的代谢产物作为评估指标,探讨有毒中药配伍减毒的可能机制,以期为临床用药以及毒理学的研究提供参考。
The toxicity of toxic Chinese medicines is complex,and the purpose of attenuating toxicity is often achieved by means of compatibility,but the toxicity change after compatibility is not clear,so the toxicity assessment after the compatibility of toxic Chinese medicines is of great importance and is an important link before clinical use.Metabolomics has significant advantages in evaluating drug toxicity,but at present there is a lack of systematic discussion on the assessment of toxicity after compatibility attenuation,so the author had sorted out the relevant articles on metabolomics applied to the compatibility and attenuation of toxic Chinese medicines in recent years.The author discussed the metabolomics and metabolomics in pairs and compounds containing toxic Chinese medicines,compared the toxic biomarkers and metabolic pathways before and after compatibility,and used metabolites that change in the metabolic process as evaluation indicators to explore the possible mechanisms of toxic Chinese medicine compatibility and attenuation,in order to provide a reference for clinical drug use and toxicology research.
作者
劳秋荣
袁颢宸
王花欣
王宁
马婷
LAO Qiurong;YUAN Haochen;WANG Huaxin;WANG Ning;MA Ting(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Provincial Collaborative InnovationCenter for Classic Recipes of Traditional Chinese Medicine,Jinan 250355,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2024年第2期866-870,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金青年科学基金项目(No.82004087)
山东省中医药科技发展计划项目(No.2019-0039)
山东中医药大学科学技术史学科培养项目(No.2021KJSKFKT-A13)。
关键词
代谢组学
有毒中药
配伍减毒
中药复方
毒性评估
中药药对
研究进展
Metabolomics
Toxic Chinese medicine
Compatibility and detoxification
Chinese herbal compounds
Toxicity assessment
Chinese herbal pairs
Research progress
作者简介
通信作者:马婷,山东省济南市长清区大学科技园大学路4655号山东中医药大学,邮编:250355,电话:0531-89628060,E-mail:mastermt77@sina.com;王宁,山东省济南市长清区大学科技园大学路4655号山东中医药大学,邮编:250355,电话:0531-89628059,E-mail:zywn1992@163.com。
