摘要
由于中药及民族药生物样品中未知化合物种类多、组成复杂、代谢物浓度差异大等原因,导致精确分析代谢产物有一定难度。色谱-质谱联用技术结合了色谱卓越的分离能力与质谱准确的定性定量优势,应用于分析中药及民族药物中的单味药与复方药物的代谢组学,已成为药物代谢组学研究的理想工具。综述色谱-质谱联用技术(GC-MS、LC-MS)在中药及民族药代谢组学研究中的应用进展,为中药及民族药物的进一步研究提供参考。
It is more difficult to accurately analyze metabolites,due to many kinds of unknown compounds,complex compositions and large concentration differences of metabolites in biological samples of traditional Chinese medicine and ethnic medicine.The chromatography-mass spectrometry combined with the excellent separation ability of chromatography and the accurate qualitative and quantitative advantages of mass spectrometry has been applied to analyze the metabolomics of single and compound drugs in traditional Chinese medicine and ethnic medicine,and it has become an ideal tool for drug metabolomics research.The application progress of chromatography-mass spectrometry(GC-MS,LC-MS)in metabolomics research of traditional Chinese medicine and ethnic medicine was reviewed,which provided reference for further study of traditional Chinese medicine and ethnic medicine.
作者
苏日古嘎
陈佳麟
徐宁
王曦烨
许良
Suriguga;Chen Jialin;Xu Ning;Wang Xiye;Xu Liang(College of Chemistry and Chemical Engineering,Inner Mongolia University for the Nationalities,Tongliao 028042,China)
出处
《亚太传统医药》
2021年第6期198-202,共5页
Asia-Pacific Traditional Medicine
基金
国家自然科学基金(30760299、81560702)
关键词
色谱-质谱联用技术
中药
民族药
代谢组学
应用进展
Chromatography-Mass Spectrometry
Traditional Chinese Medicine
Ethnic Medicine
Metabonomics
Application Progress
作者简介
苏日古嘎(1996-),女,内蒙古民族大学硕士研究生,研究方向为色谱分析。E-mail:1341468400@qq.com;通讯作者:许良(1966-),男,博士,内蒙古民族大学教授,研究方向为蒙药标准化及蒙药炮制方法。E-mail:nmgxl66@163.com
