摘要
目的研究川乌-地榆冻干粉(1∶2)酒溶液、水溶液中新乌头碱、乌头碱、次乌头碱的含量变化。方法采用高效液相色谱法(HPLC)对川乌配伍地榆前后新乌头碱、乌头碱、次乌头碱的含量进行测定。结果川乌-地榆冻干粉(1∶2)酒溶液3种双酯型生物碱的含量较单川乌冻干粉酒溶液下降了97.3%;川乌-地榆冻干粉(1∶2)水溶液3种双酯型生物碱的含量较单川乌冻干粉水溶液下降了96.7%。结论川乌-地榆冻干粉(1∶2)酒溶液、水溶液可降低川乌中新乌头碱、乌头碱、次乌头碱的含量,起到减毒的作用,为揭示制川乌减毒配伍机制提供指导。
Objective To study the changes of the contents of Neoaconitine,Aconitine and Hypoaconitine in Radix Aconiti(RA)-Sanguisorba officinalis L(SOL)lyophilized powder(1∶2)wine solution and aqueous solution.Method The contents of Neoaconitine,Aconitine and Hypoaconitine before and after RA-SOL were determined by high performance liquid chromatography(HPLC).Results The content of three diester alkaloids in RA-SOL lyophilized powder(1∶2)wine solution decreased by 97.3%compared with that of RA freeze-dried powder solution.The content of three diester alkaloids in RA-SOL lyophilized powder(1∶2)aqueous solution decreased by 96.7%compared with the aqueous solution of RA freeze-dried powder.Conclusion The RA-SOL of lyophilized powder(1∶2)can reduce the content of Neoaconitine,Aconitine and Hypoaconitine in RA,play a role in attenuation,and provide guidance for revealing the mechanism of drug reduction and compatibility in the preparation of RA.
作者
邰通芝
陈桃香
何席呈
唐娟
胡家震
胡成刚
TAI Tongzhi;CHEN Taoxiang;HE Xicheng;TANG Juan;HU Jiazhen;HU Chenggang(Guizhou University of Chinese Medicine,Guiyang 550025,China)
出处
《湖北民族大学学报（医学版）》
2024年第1期41-44,共4页
Journal of Hubei Minzu University(Medical Edition)
基金
贵州中医药大学苗医药标准研究(04021016101)。
关键词
川乌
地榆
配伍减毒
新乌头碱
乌头碱
次乌头碱
生物碱
Radix Aconiti
Sanguisorba officinalis L
Compatibility to reduce toxicity
Neo-aconitine
Aconitine
Times of aconitine
Alkaloids
作者简介
第一作者:邰通芝,女,硕士研究生,主要研究方向:中药及民族药基础研究与开发;通信作者:胡成刚,男,教授,主要研究方向:中药及民族药基础研究与开发。
