摘要
中药挥发油是通过经典或创新提取方式从芳香中药材中获得的油性芳香液体,具有多种生物活性,广泛应用于不同疾病的防治。但挥发油理化性质不稳定,在光照、氧气、温度、金属杂质等诸多因素影响下,活性成分易通过氧化、分解、异构化、光环加成等反应途径发生转变,其含量与组成的变化导致挥发油品质下降、临床风险增加。如何通过环境控制与制剂技术保护挥发油活性成分,以维持挥发油理化性质稳定是一关键问题。因此,在综述中药挥发油特点及主要化学成分组成的基础上,深入分析影响中药挥发油稳定性的诸多因素,阐明中药挥发油活性成分变化的途径及机制,进一步总结中药挥发油稳定性的保护策略,为挥发油的制药大生产质量控制及临床安全使用提供参考。
Volatile oil from traditional Chinese medicine is oily aromatic liquid obtained from aromatic Chinese medicinal materials by classical or innovative extraction methods.They have diverse biological activities and are widely used in the prevention and treatment of various diseases.However,the physical and chemical properties of volatile oil are unstable.Under the influence of light,oxygen,temperature,metal impurities and other factors,the active ingredients are easily transformed through reaction pathways such as oxidation,decomposition,isomerization,and photocycloaddition,and changes in their content and composition lead to decreased volatile oil quality and increased clinical risks.How to protect the active ingredients of volatile oil through environmental control and formulation technology to maintain the stability of the physical and chemical properties of volatile oil is a key issue.Therefore,on the basis of reviewing the characteristics and main chemical components of volatile oil,many factors affecting the stability of volatile oil were deeply analyzed in this paper,and the ways and principles of changes in active components of volatile oil were clarified,and the relevant protection strategies for stabilization of volatile oil were further summarized,in order to provide reference for quality control of volatile oil in large-scale pharmaceutical production and clinical safe use.
作者
吴意
万娜
刘阳
林瑞华
张雨恬
郭冬云
廖嘉宝
周同辉
伍振峰
杨明
WU Yi;WAN Na;LIU Yang;LIN Rui-hua;ZHANG Yu-tian;GUO Dong-yun;LIAO Jia-bao;ZHOU Tong-hui;WU Zhen-feng;YANG Ming(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China;State Key Laboratory of Innovation Drug and Efficient Energy-Saving Pharmaceutical Equipment,Jiangxi University of Chinese Medicine,Nanchang 330004,China;China Resources Sanjiu Medical&Pharmaceutical Co.,Ltd.,Shenzhen 518110,China;Hangzhou Jintong Health Technology Co.,Ltd.,Hangzhou 310004,China;Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第21期6900-6908,共9页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(82060720)
国家自然科学基金资助项目(82074026)
江西省重大科技研发专项(20194ABC28009)
省级大学生创新创业计划项目(S202110412005)
省级大学生创新创业计划项目(S202210412062)
省级大学生创新创业计划项目(S202210412073)
江西省卫生健康委科技计划项目(202210757)
江西省中医药科研计划项目(2018A318)。
关键词
中药挥发油
稳定性
影响因素
变化机制
保护策略
volatile oil from traditional Chinese medicine
stability
influencing factors
changing mechanisms
protection strategies
作者简介
吴意(1997-),女,硕士研究生。E-mail:2715818490@qq.com;通信作者:伍振峰,教授,博士生导师,主要从事中药新剂型与新技术/中药制药装备研究。Tel:(0791)87118658E-mail:zfwu527@163.com;通信作者:杨明,教授,博士生导师,主要从事中药制剂学研究。Tel:(0791)87118108E-mail:lab215@163.com。
