摘要
精油因其成分极易发生氧化损伤、化学转化或聚合反应,存在不稳定性、低水溶性和低生物利用度等主要内在问题,制约了其在产品开发领域的应用。与其他递药系统相比,纳米结构脂质载体(nanostructured lipid carriers,NLCs)可以克服其他胶体载体,如乳剂、脂质体、聚合物纳米粒和固体脂质纳米粒等存在的部分局限性。NLCs是一种高效、稳定的生物活性物质递送系统。它凭借独特的脂质性质(固体脂质和液体脂质混合),可以克服精油自身的缺点,使精油免受不利环境的影响,从而提高精油的稳定性、生物利用度和安全性,并实现缓、控释释放。在精油-纳米结构脂质载体(EOs-NLCs)体系中,精油作为具有生物活性和药用特性的特殊液体脂质,通过改变混合脂质的结构特性,充分发挥药辅合一的作用。该文基于纳米载体系统的发展,介绍了EOs-NLCs的组成及结构特性,从NLCs对精油理化性质、物理稳定性和活性成分的释放等方面的影响,阐明其如何提高精油稳定性。此外,还介绍了该体系在制药、食品、化妆品和护肤品等领域的应用现状。该综述旨在为纳米结构脂质载体(NLCs)提高精油稳定性及其应用提供一定的借鉴,从而为其在各领域的应用提供有益参考。
Essential oils are easy to cause oxidative damage,chemical transformation or polymerization,and have some intrinsic problems,such as instability,low water solubility and low bioavailability,which restrict their application in the fields of product development.Nanostructured lipid carriers(NLCs)can overcome some of the restrictions of other colloidal carriers,such as emulsions,liposomes,polymer nanoparticles and solid lipid nanoparticles.NLC is an efficient and stable delivery system for bioactive substances.With unique lipid properties(mixture of solid and liquid lipid),it can overcome the disadvantages of essential oils and protect them from adverse environments,thus improving the stability,bioavailability and safety of essential oils,and achieve sustained release and controlled release.In EOs-NLCs system,essential oils,as special liquid lipid with biological activities and medicinal properties,can fully play the role of medicine-adjuvant integration by changing the structural characteristics of mixed lipid.Based on the development of nanocarriers system,this paper introduces the composition and structural characteristics of EOs-NLCs,and clarifies how to improve the stability of essential oils based on the effects of NLCs on physical and chemical properties,physical stability and release of active components of essential oils.In addition,it also introduces the application of the system in the fields of pharmaceutical,food,cosmetics and skin care products.This review aims to provide some references for improving the stability of essential oils and their applications by using NLCs.
作者
李怡
伍振峰
况弯弯
李远辉
陈冰玉
杨明
LI Yi;WU Zhen-feng;KUANG Wan-wan;LI Yuan-hui;CHEN Bing-yu;YANG Ming(State Key Laboratory of Innovation Drug and Efficient Energy-Saving Pharmaceutical Equipment,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Key Lab of Modern Preparation of Traditional Chinese Medicine under Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第3期523-530,共8页
China Journal of Chinese Materia Medica
基金
江西省“双一流”学科(中药学)建设项目(JXSYLXK-ZHYAO085)
国家级大学生创新创业训练项目(2018104120011).
关键词
纳米结构脂质载体
挥发油
稳定性
脂质
综述
nanostructured lipid carriers
volatile oils
stability
lipid
review
作者简介
通讯作者:伍振峰,博士,副教授,主要从事中药新剂型与新技术/中药制药装备研究,Tel/Fax:(0791)87118658,E-mail:zfwu527@163.com;通讯作者:杨明,教授,博士生导师,主要从事中药新剂型与新技术/中药新药开发研究,Tel/Fax:(0791)87118108,E-mail:lab215@163.com;李怡,硕士研究生,E-mail:liyijulyjuly@163.com
