摘要
目的 探讨米克(MEEK)植皮术联合碱性成纤维细胞生长因子(b-FGF)在大面积深度烧伤创面修复中的临床价值。方法 回顾性分析2016年1月—2021年11月本院收治的68例大面积深度烧伤患者临床资料,根据治疗方式差异将接受MEEK植皮术治疗的患者作为对照组(34例),将接受MEEK植皮术联合b-FGF治疗的患者作为研究组(34例)。比较两组患者的创面愈合时间、皮片融合时间、住院时间,治疗前后的降钙素原(PCT)、血清淀粉样蛋白(SAA)、超敏C-反应蛋白(hs-CRP)水平,术后2周的皮片成活率、临床疗效及术后并发症发生率。结果 研究组的皮片融合时间、创面愈合时间、住院时间短于对照组,研究组患者术后2周的疗效优良率(94.12%Vs 73.53%)高于对照组,研究组患者的皮片成活率高于对照组,以上差异均有统计学意义(P均<0.05);研究组与对照组术后并发症总发生率(17.65%Vs 23.53%)及治疗前的PCT、SAA、hs-CRP水平比较,差异无统计学意义(P>0.05),但治疗后两组的PCT、SAA、hs-CRP水平均高于治疗前,同时研究组低于对照组,差异有统计学意义(P<0.05)。结论 MEEK植皮术联合b-FGF治疗可促进大面积深度烧伤患者创面愈合,提高患者皮片成活率及患者预后质量,且具有操作简单、皮源充足等优势。
Objective To investigate the clinical value of Meek skin grafting combined with basic fibroblast growth factor(b-FGF) in the repair of large-area deep burn wounds.Methods The clinical data of 68 patients suffered with large-area deep burn those were treated in Meizhou traditional Chinese medicine hospital from January 2016 to November 2021 were retrospectively analyzed. According to the difference of treatment methods, the patients treated with MEEK skin grafting were divided into control group(34 cases) and the patients treated with MEEK skin grafting combined with b-FGF were divided into study group(34 cases). The wound healing time, skin graft fusion time, hospital stay, the levels of procalcitonin(PCT), serum amyloid(SAA) and high-sensitivity C-reactive protein(hs-CRP) before and after treatment, the skin graft survival rate, clinical curative effect and the incidence of postoperative complications were compared between the two groups. Results The skin graft fusion time, wound healing time and hospitalization time of the study group were shorter than those of the control group. The excellent and good rate of the efficacy in study group(94.12% vs 73.53%) two weeks after operation was higher than that of the control group, and the skin graft survival rate of the study group was higher than that of the control group(all P<0.05). There was no significant difference between the study group and the control group in the total incidence of postoperative complications(17.65% vs 23.53%) and the levels of PCT, SAA and hs CRP before treatment(P>0.05), but the levels of PCT, SAA and hs CRP in the two groups after treatment were higher than those before treatment, and the study group was lower than that in the control group, the difference was statistically significant(P<0.05).Conclusions Meek skin grafting combined with b-FGF could promote the wound healing of patients with large-area deep burn, improve the survival rate of skin graft and the quality of prognosis, and has the advantages of easy operation and sufficient skin source.
作者
周文涛
何国
谢恩光
蔡翰翔
马焕霞
Zhou Wentao;He Guo;Xie Enguang;Cai Hanxiang;Ma Huanxia(Department of burn,plastic and wound repair,Meizhou hospital of traditional Chinese medicine,Meizhou,Guangdong,514000,China)
出处
《齐齐哈尔医学院学报》
2022年第14期1320-1323,共4页
Journal of Qiqihar Medical University
作者简介
通信作者:周文涛,Email:thdn547@163.com。
