摘要
雌激素是女性生殖系统分泌的重要激素,其主要功能与生殖、生长及发育有关。研究表明,雌激素还具有调节血管收缩、抗氧化应激、抗炎和神经保护等生物学功能,还会影响大脑结构和网络。有研究显示,雌激素与脑白质高信号(white matter hyperintensities,WMHs)的发生和发展密切相关。文章就雌激素和更年期激素替代治疗与WMHs之间的关系及其可能的病理生理学机制进行了综述。
Estrogen is an important hormone secreted by the female reproductive system.Its main function is associated with reproduction,growth and development.Studies have shown that estrogen has biological functions such as regulating vasoconstriction,antioxidant stress,anti-inflammatory and neuroprotection,and also affects brain structure and network.Studies have shown that estrogen is closely associated with the occurrence and development of white matter hyperintensities(WMHs).This article reviews the relationship between estrogen and menopausal hormone replacement therapy and WMHs,and their possible pathophysiological mechanisms.
作者
史晓英
何洪真
郭星
冯潇潇
赵金叶
吕佩源
Shi Xiaoying;He Hongzhen;Guo Xing;Feng Xiaoxiao;Zhao Jinye;Lyu Peiyuan(Graduate School of Hebei Medical University,Shijiazhuang 050017,China;Department of Neurology,Hebei General Hospital,Shijiazhuang 050051,China;Graduate School of North China University of Science and Technology,Tangshan 063210,China;Graduate School of Hebei North University,Zhangjiakou 075000,China)
出处
《国际脑血管病杂志》
2021年第12期943-947,共5页
International Journal of Cerebrovascular Diseases
基金
河北省政府资助临床医学优秀人才培养项目(冀财社:2019-139-5)
河北省高端人才资助项目(6833452)。
关键词
雌激素类
激素替代疗法
脑小血管疾病
白质
磁共振成像
危险因素
Estrogens
Hormone replacement therapy
Cerebral small vessel diseases
White matter
Magnetic resonance imaging
Risk factors
作者简介
通信作者:吕佩源,Email:peiyuanha@163.com。
