摘要
糖尿病性视网膜病变(DR)是糖尿病常见且严重的微血管并发症,也是导致50岁及以上成年人失明和视力障碍的主要原因。近年来,糖尿病患病率持续上升,人口老龄化日渐加剧,DR的发病率显著增加,成为全球公共卫生面临的重大挑战。DR的病理机制复杂,包括高血糖诱导的代谢紊乱、氧化应激、炎症反应、血管病变以及神经变性等。有研究结果表明,雌激素通过抗炎、抗氧化、保护血管及抑制新生血管生成等作用可潜在延缓DR进展。本文中笔者总结了雌激素在DR中作用机制的最新研究进展,旨在为DR的临床治疗提供新思路。
Diabetic retinopathy(DR)is a common and serious microvascular complication of diabetes,which is the leading cause of blindness and vision impairment in adults aged 50 and above.In recent years,the prevalence of diabetes has been rising continuously,and with an aging population,the incidence of DR has significantly increased,posing a major challenge to global public health.The pathological mechanisms of DR are complex,involving hyperglycemia-induced metabolic disorders,oxidative stress,inflammatory responses,vascular abnormalities,and neurodegeneration,etc.It has been demonstrated that estrogen potentially delays DR development through its anti-inflammatory,antioxidant,vascular protective,and anti-angiogenic effects.The latest research progress on the mechanisms of estrogen in DR were summarized,which to provide the new insights for the clinical treatment of DR in this paper.
作者
王子琪
李萍
蔡标
杨秀敏
Wang Ziqi;Li Ping;Cai Biao;Yang Xiumin(Department of Fundus Diseases,Hefei AIER Eye Hospital,Hefei 230000,China;AIER Eye Medical Center,Anhui Medical University,Hefei 230000,Chin)
出处
《中华眼科医学杂志（电子版）》
2024年第3期187-192,共6页
Chinese Journal of Ophthalmologic Medicine(Electronic Edition)
基金
安徽医科大学校基金资助项目(2022xkj135)。
作者简介
通信作者:王子琪,Email:1097370754@qq.com。
