摘要
阿尔茨海默病(AD)是痴呆症的最主要亚型,也是65岁以上人群死亡的第五大原因,其发病机制十分复杂,涉及慢性神经炎症等诸多因素,并受到遗传、环境和生活方式等多种因素影响,因此其研究进展缓慢,缺乏有效的防治手段。近年来,人们认识到肠道菌群与大脑相互作用,称之为微生物-肠道-大脑轴,该轴涉及代谢、内分泌、神经和免疫通路,这些通路对维持大脑稳态至关重要。最近的证据表明,肠道生态失调与阿尔茨海默病相关,并可能通过多种途径导致AD的发生发展和病理变化,尽管具体机制并不明确,但是通过药物或其他手段调节肠道菌群为AD的预防和治疗提供了新的方向。
Alzheimer′s disease(AD)is the leading form of dementia and the fifth leading cause of death in people over 65.The pathogenesis of AD is very complex,involving chronic neuroinflammation and neurodegeneration and affected by multiple factors such as genetics,environment and lifestyle.Therefore,its research progress is slow and there is a lack of effective prevention and treatment means.In recent years,it has been recognized that the gut flora interacts with the brain,known as the microbial-gut-brain axis,which involves metabolic,endocrine,neurological and immune pathways that are critical for maintaining brain homeostasis.Recent evidences have shown that intestinal dysbiosis is related to a variety of neurological diseases and may lead to the occurrence,development and pathological changes of AD through a variety of ways.Although the specific mechanism is not clear,the regulation of intestinal flora through drugs or other means can provide a new direction for the prevention and treatment of AD.
作者
陆守荣
张云云
郁洁
杨颖
徐侨
张炳山
王卓
洪侃
Lu Shourong;Zhang Yunyun;Yu Jie;Yang Ying;Xu Qiao;Zhang Bingshan;Wang Zhuo;Hong Kan(Department of Geriatric,the Affiliated Wuxi People′s Hospital of Nanjing Medical University,Wuxi 214000,China;不详)
出处
《中国临床保健杂志》
CAS
2021年第6期855-860,共6页
Chinese Journal of Clinical Healthcare
基金
江苏省自然科学基金青年项目(BK20190148)
江苏省无锡市卫生健康委员会青年项目(Q201914)
江苏省无锡市“双百”中青年医疗卫生拔尖人才项目。
作者简介
陆守荣,副主任医师,Email:lushourong6@163.com;通信作者:洪侃,主任医师,副教授,硕士研究生导师,Email:2898456291@qq.com。
