摘要
目的:观察补肾活血周期疗法联合淋巴细胞主动免疫治疗免疫性复发性流产的疗效及对血清封闭抗体(BA)的影响。方法:选取102例免疫性复发性流产患者作为研究资料。将入选患者分为对照组与研究组,对照组采取单纯淋巴细胞主动免疫治疗,研究组在采用对照组治疗方法的同时,应用中医补肾活血周期疗法,治疗至患者妊娠12周时停止,对比两组患者妊娠结局;观察两组封闭抗体阳性率、封闭抗体转阳时间;观察治疗前后两组患者淋巴细胞免疫表型的变化情况。结果:研究组BA阳性率高于对照组(P<0.05);研究组妊娠结局整体情况优于对照组(P<0.05);研究组治疗后BA转阳时间较对照组短(P<0.05)。治疗后两组各项淋巴细胞免疫表型均较治疗前改善(P<0.05);但研究组CD_3^+T、CD_4^+T、CD_4^+THLA-DR^+/CD_4^+、CD_3^-CD56^+NK、CD_4^+TCD25^+CD127^(dim)Treg均优于对照组(P<0.05)。结论:补肾活血周期疗法联合淋巴细胞主动免疫治疗,能够缩短封闭抗体转阳时间,提高封闭抗体阳性率与免疫表型的表达水平,有效改善妊娠结局。
Objective： Explore the therapeutic effect of Bushen Huoxue therapy combined with active lymphocyte immunization in the treatment of recurrent immunological abortion and its effect on serum closed antibody （BA）.Methods： 102 patients with recurrent immunological abortion admitted were selected as the study data. To selected patients were divided into control group and research group, control group take the pure lymphocyte immune treatment actively, the team in the control group treatment method at the same time, the application of traditional Chinese medicine Bushen Huoxue therapy of treatment, the treatment to the patients with pregnancy stop at 12 weeks, compared two groups of patients with pregnancy outcome; the positive rate of the closed antibody and the time of the closed antibody were observed. The changes of lymphocyte immunophenotype before and after treatment were observed. Results： The positive rate of BA in the study group was higher than that in the control group（ P 〈0.05）. The overall pregnancy outcome of the study group was better than that of the control group（ P 〈0.05）. Compared with the control group, the time of BA was shorter after treatment（ P 〈0.05）. After treatment, all lymphocyte immunopheno types of the two groups were improved（ P 〈0.05）. However, CD 3 ＋ T、CD 4 ＋ T、CD 4 ＋ THLA-DR ＋ /CD 4 ＋ 、CD 3 -CD56^＋ NK、CD 4 ＋ TCD25 ＋ CD127 dim Treg in the study group were better than those in the control group（ P 〈0.05）. Conclusion：Bushen Huoxue therapy combined with the active immunotherapy of lymphocyte, can shorten the time of closing antibody to positive, and improve the positive rate of closed antibody and the expression level of immunophenotype.
作者
王文娟
陶利利
刘杰
卢宗林
Wang Wenjuan;Tao Lili;Liu Jie(Department of Reproductive Medicine,The First Hospital of Traditional Chinese Medicine in Luoyang（Luoyang 471000)
出处
《陕西中医》
2018年第11期1573-1575,1579,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
河南省洛阳市科学技术局科研课题(1870003A)
关键词
流产/中西医结合疗法
@补肾活血周期疗法
Abortion/integrated Chinese traditional and western medicine therapy
@Bushen Huoxue therapy
