摘要
目的观察补肾调肝汤结合雌激素治疗卵巢储备功能低下引发不孕症及复发性自然流产患者的临床疗效。方法 106位卵巢储备功能低下的不孕症及复发性自然流产患者,随机分为中西医治疗组54例和西药治疗组52例,西药治疗组接受炔雌醇、补佳乐及达芙通激素治疗;中西医治疗组在西药基础上加补肾调肝汤,两组治疗均3个月为1个疗程,共6个月。比较治疗前后血清促卵泡激素(follicle stimulating hormone,FSH)水平、FSH/LH(黄体生成素,luteinizing hormone,LH)比值、雌二醇(estradiol,E2)水平、睾酮(testosteron,T)水平的变化,并对治疗后妊娠结局进行对比分析。结果与用药前比较,两组患者治疗后血清FSH及FSH/LH比值均降低(P<0.05),E2及T均略升高(P>0.05),且在FSH及FHS/LH方面中西医治疗组优于西药组(P<0.05)。中西医治疗组妊娠率为40%,对比西药组(11.5%),高于西药组(P<0.05),且中西医结合结合治疗4~6个月妊娠率高。结论补肾调肝汤结合雌激素治疗卵巢储备功能低下性不孕症和复发性自然流产疗效优于西药组;中西医结合治疗3个月后再备孕患者妊娠率明显提高。
Objective:To evaluate the efficacy of integrated Traditional Chinese Bushen Tiaogan(BSTG)Decoction and Estrogen Medicine(TCM-EM)in the treatment of infertility and repeated spontaneous abortion patients with diminished ovarian reserve and probe the therapeutic mechanism.Methods:A total of 106 infertility or repeated spontaneous abortion patients with diminished ovarian enrolled at our hospital were retrospectively studied.These patients were randomly separated into TCM-EM group and Estrogen Medicine(EM)group randomly,and given the treatment of Estradiol valerate and Ethinylestradiol as well as Dydrogesterone in the EM group for six months;while the TCM-EM group:BSTG Decoction and the same western medicine as the EM group together for six months.The differences of pregnancy rate and reproductive hormones before and after the treatment were observed and compared.Results:The level of serum follicle stimulating hormone(FSH)and ratio of follicle stimulating hormone and Luteinizing hormone(FSH/LH)were declined(P<0.05),and the level of serum estradiol(E2)and testosterone(T)slightly increased(P>0.05)after treatment.40% of the patients in the TCM-EM group had successful pregnancy and delivery(only with one abortion finally),while the rate was 11.5% in EM group(P<0.05).After the integrative treatment for more than three months took higher pregnant rate.Conclusion:The integrated TCM-EM has obvious curative efficacy on women with diminished ovarian reserve rather than EM group,which can improve the ovarian function and pregnancy opportunity.To a certain extent,testosterone can reflect the ovarian reserve and can be used as a new important indicator to evaluate the ovarian reserve.The integrated TCM-EM treatment showed good clinical efficacy toward the DOR patients.
作者
李晶
王韵
吴克瑾
王文君
LI Jing;WANG Yun;WU Kejin;WANG Wenjun(Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200090,China;Yujin National Famous Ancient TCM Academic Expertise Heritage Research Room,Shanghai 200090,China)
出处
《辽宁中医药大学学报》
CAS
2020年第1期113-116,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
俞瑾全国名老中医传承工作项目
上海市科委医学引导(中医)项目(15401931800).
关键词
卵巢储备功能低下
不孕症
复发性自然流产
补肾调肝汤
雌激素
diminished ovarian reserve
infertility
repeated spontaneous abortion
Bushen Tiaogan decoction
estrogen
作者简介
李晶(1982-),女,河北丰润人,主治医师,硕士,研究方向:妇科生殖内分泌疾病、中医妇科疾病临床诊治;通讯作者:王文君(1964-),女,上海人,主任医师,博士研究生导师,博士,研究方向:妇科生殖内分泌疾病、PCOS、POI、复发性流产等疾病的中西医结合临床诊治及基础研究。E-mail:wwjw@aliyun.com。
