摘要
目的:探讨抗磷脂综合征导致复发性流产患者的免疫治疗效果。方法:选取2018年1月-2019年6月我院120例抗磷脂综合征导致复发性流产患者作为研究对象,随机分为观察组(n=60)及对照组(n=60),对照组采用低分子肝素、阿司匹林治疗,观察组在对照组的基础上采用人免疫球蛋白治疗,观察并比较两组患者激素水平、抗磷脂抗体转阴情况及流产率。结果:治疗前,两组患者激素水平差异无统计学意义(P>0.05);治疗后,两组患者HCG、E2、P激素水平显著提高,观察组患者HCG、E2、P激素水平明显高于对照组(P<0.05);观察组患者流产率明显低于对照组(P<0.05);研究组患者抗磷脂抗体转阴率明显高于对照组,差异具有统计学意义(P<0.05)。结论:抗磷脂综合征导致复发性流产患者的免疫治疗效果显著,有效改善患者临床症状,提高抗磷脂抗体转阴率,改善患者妊娠结局,值得推广。
Objective:To investigate the effect of immunotherapy on patients with recurrent abortion caused by antiphospholipid syndrome.Method:Choose 2018 cases of our hospital from 120-June 2019 in January for antiphospholipid syndrome in patients with recurrent abortion as the research object,were randomly divided into observation group(n=60)and control group(n=60)and control group with low molecular heparin and aspirin therapy,observation group in the control group on the basis of using human immunoglobulin treatment,observe and compare the two groups of patients with hormone levels,turn for antiphospholipid antibodies and abortion rate.Results:Before treatment,there was no statistically significant difference in hormone levels between the two groups(P>0.05).After treatment,the levels of HCG,E2 and P hormones in the two groups were significantly increased,and the levels of HCG,E2 and P hormones in the observation group were significantly higher than those in the control group(P<0.05).The abortion rate in the observation group was significantly lower than that in the control group(P<0.05).The negative conversion rate of anti-phospholipid antibody in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:The immunotherapy effect of antiphospholipid syndrome in patients with recurrent abortion is significant,which can effectively improve the clinical symptoms,improve the negative rate of antiphospholipid antibody,and improve the pregnancy outcome of patients.
作者
葛泽锋
陈秀娟
GE Ze-feng;CHEN Xiu-juan(Department of Rheumatology and Immunology,Langfang Red Cross Bazhou Development Zone Hospital,Langfang Heibei 065000,China;Ultrasound Department,Bazhou Maternal and Child Health Hospital,Bazhou Hebei 065000,China)
出处
《医学食疗与健康》
2019年第11期1-1,3,共2页
Medical Diet and Health
关键词
抗磷脂综合征
复发性流产
免疫治疗
Anti-phospholipid Syndrome
Recurrent Abortion
Immunotherapy
Clinical Effect
