摘要
中药具有多成分、多靶点、多途径的特色和复杂性。中药药效物质基础研究是阐释中药整体功效及作用本质的核心环节,现阶段中药药效物质基础研究方法主要包括基于中药体内药效活性追踪的有效部位寻找、配伍与拆方研究,基于多种仪器联用表征的化学指纹图谱与效应关联研究,基于体内代谢过程的血清药物化学与方证代谢组学研究,基于体外模型生物活性发现的细胞膜色谱与仿生技术研究,以及基于计算机模拟的网络药理学研究等方法。笔者通过查阅近几年的文献,对该领域的研究方法进行归纳总结,旨在对中药复方药效物质基础研究方法提供理论依据。
Traditional Chinese medicine （TCM） has the characteristics and complexities of multi-component, multi-target and muhi- way. The study of TCM compound efficacy material basis is the core part in illuminating the effect and mechanism of TCM. So many methods were involved in the researches on material foundation including the effective part searching, compatibility and its disassem- bled prescriptions investigating based on pharmacological activity tracking in vivo ; the association analysis between chemical fingerprints characterized by a variety of instruments and efficacy; serum pharmacochemistry and Chinmedomics based on metabolic processes in vi- vo ; cell membrane chromatography and bionic technology based on activity discovering in vitro ; and network pharmacology based on the computer simulation. The paper summarized the research methods in this field by consulting and concluding some document data of re- cent years, aiming to provide a theoretical foundation for studying on the effective material foundation of compound prescription of tradi- tional Chinese medicine.
作者
张王宁
李爱平
李科
秦雪梅
ZHANG Wang-ning;LI Ai-ping;LIKe;QIN Xue-mei(Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Shanxi University, Taiyuan 030006, Chin)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2018年第10期761-764,共4页
Chinese Pharmaceutical Journal
基金
国家自然科学基金项目资助(31570346)
黄芪生长年限与化学成分积累规律研究资助(201605D211030)
山西省中药产业重点科技攻关项目资助:道地药材种质资源与规范化生产技术研究资助(201603D311101)
山西省药材行业标准-恒山黄芪药材与精品饮片商品等级标准研究资助(2014ZD0401)
关键词
中药
复方
物质基础
研究方法
Chinese medicine
compound
material foundation
research method
作者简介
张王宁，女，硕士研究生研究方向：中药体内药物分析;通讯作者：秦雪梅，女，博士，教授研究方向：中药质量控制及新药研发方面Tel：（0351）7011501E-mail：qinxm@sxu．edu．cn
