摘要
目的:探讨血清同型半胱氨酸(Hcy)及血脂水平在慢性酒精中毒性脑病(CAE)发生与发展中的作用,并探究依达拉奉+维生素联合干预的治疗效果。方法:CAE患者63例为CAE组,按饮酒年限不同分为3亚组:低、中、高年限亚组,分别为31例、24例和8例;并根据有无颈动脉粥样硬化(CAS)斑块分为2亚组:无CAS斑块亚组38例和有CAS斑块亚组25例。同时选取我院同期63例男性健康体检者为对照组。对照组:不用任何药物治疗;CAE组:予以依达拉奉+维生素联合方案治疗。记录比较各组和各亚组血清Hcy、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及总胆固醇(TC)水平;CAE组治疗前后简易智能精神状态检查量表(MMSE)评分;观察并记录CAE组用药期间不良反应。结果:与健康对照组对比,CAE组血清Hcy、TG、LDL-C及TC水平均显著上升(P<0.01)。CAE组患者血清Hcy水平随饮酒年限的增加而逐渐上升(P<0.01)。CAE组中有CAS斑块亚组患者血清Hcy水平显著高于无CAS斑块者(P<0.01)。与治疗前相比,CAE组治疗后血清Hcy、TG、LDL-C及TC水平均显著降低(P<0.01);MMSE评分显著升高(P<0.01)。结论:在CAE发生与发展中血清Hcy及血脂水平发挥着十分重要的作用。
Objective： To explore the changes of homocysteine （Hey） and lipid levels in the development and progression of chronic alcoholic encephalopathy （CAE） and to explore the therapeutic effect of edaravone com- bined with vitamin B. Methods： Sixty-three cases with CAE were enrolled as CAE group. According to the du- ration of drinking they were divided into 3 sub-groups and according to carotid atherosclerosis （CAS） plaques they were further divided into two sub-groups. Sixty-three healthy cases were enrolled as control group. No medical therapy was provided to those in the control group, while edaravone combined with vitamin B was provided to CAE group. The levels of blood Hey, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C） and total cholesterol （TC） in both the CAE group and control group were measured. Cases in the CAE group were tested by mini mental state examination （MMSE） before and after therapy. Results： The Hey, TG, LDL-C and TC lev- els in the CAE group were significantly higher than those in the control group （P〈0.01）. The Hey level in the CAE group increased with the increasing years of drinking （P〈0.01）. Cases with CAE plaque in the CAE group had higher Hey level than those without CAE plaque （P〈0.01）. Compared with that before therapy, Hey, TG, LDL-C, TC levels and MMSE score in the CAE group significantly increased （P〈0.01）. Conclusion： Hey and lipids level could be significant important factors for the development and progression of CAE.
作者
刘星亮
岳秉宏
范磊
潘妍婷
宋征宇
LIU Xing-liang YUE Bin-hong FAN Lei PAN Yah-ring SONG Zheng-yu(Department of Neu- rology, The First Hospital of Hebei Horth University,, Heibei 075000, Chin)
出处
《神经损伤与功能重建》
2017年第4期323-326,共4页
Neural Injury and Functional Reconstruction
基金
张家口市2013年度科学技术研究与发展指导计划项目(No.1321049D)
作者简介
通讯作者刘星亮m18165356509_1@163．com
