摘要
目的探究同型半胱氨酸(Hcy)对冠心病(CHD)患者脑出血发病的影响。方法选取本院2014年1月—2016年1月收治的CHD脑出血患者45例为观察组,选取45例同期CHD患者为对照组。对比分析两组患者的CHD年限、糖尿病、高血压、饮酒史、Hcy、低密度脂蛋白胆固醇(LDL-C)。结果观察组CHD的年限,有糖尿病、高血压史、饮酒史患者的数据分别为(4.320.76)年、69%、71%、44%,对照组CHD的年限、有糖尿病、高血压、饮酒史患者的数据分别为(2.340.88)年、53%、49%、42%,观察组患者的冠心病年限高于对照组,有糖尿病、高血压史的患者多于对照组对比差异有统计学意义(P<0.05),两组患者有饮酒史的情况对比差异无统计学意义(P>0.05)。观察组患者血清Hcy、LDL-C分别为17.344.11μmol·L^(-1)、5.340.42mmol·L^(-1),对照组患者血清Hcy、LDL-C分别为12.502.25μmol·L^(-1)、3.140.43mmol·L^(-1)。根据四分位间距研究发现血清Hcy的水平最高组的CHD患者,脑出血发生的风险最大。结论 Hcy与CHD患者脑出血发病有一定联系,Hcy升高CHD患者脑出血几率增加。
Objective To explore the effect of serum homocysteine(Hcy)levels on cerebral hemorrhage in patients with coronary heart disease(CHD).Method Forty-five cases of cerebral hemorrhage in our hospital from January2014to January2016were selected as observation group,Forty-five patients with CHD were selected as control group.And compared the age of CHD,hidtory of diabetes,history of hypertension,drinking history,serum Hcy,LDL.Results The data of the number of CHD,diabetes,history of hypertension,drinking history of the observation group were(4.320.76)years,69%,71%,44%.The data of the number of CHD,diabetes,history of hypertension,drinking history of the observation group were(2.340.88)years,53%,49%,42%.The age coronary heart disease of the observation group was higher than the control group,the diabetes,high blood pressure history of the observation was than the control group,the difference was significant(P<0.05).There was no difference in other data,and there was no statistical significance(P>0.05).The serum levels of Hcy and LDL-C of the observation group were(17.344.11)μmol·L-1,(5.340.42)mmol·L-1,the serum levels of Hcy and LDL-C of the control group were(12.502.25)μmoml·L-1,(3.140.43)mmol·L-1,the serum LDL-C,Hcy of the observation group'patients was significantly higher than the control group,the difference was statistically significant(P<0.05).The group with highest level of serum Hcy,the risk of cerebral hemorrhage was the highest according to the four point spacing study.Conclusion The serum Hcy have a certain link with the incidence of cerebral hemorrhage in patients with CHD,with the increasing of serum Hcy in patients with CHD,the risk of cerebral hemorrhage increases.This has a great significance to the incidence of cerebral hemorrhage in patients with CHD.
作者
沈冬明
严春霞
SHEN Dong-ming;YAN Chun-xia(Department of Clinical Laboratory, the Luodian Hospital of Baoshan District Shanghai 201908, China)
出处
《脑与神经疾病杂志》
2017年第7期413-416,共4页
Journal of Brain and Nervous Diseases
关键词
血清同型半胱氨酸
冠心病
脑出血
Homocysteine
Coronary heart disease
Cerebral hemorrhage
作者简介
Corresponding author: SHEN Dong-ming,Email ：jclbb17@126.com
