摘要
目的探讨颅脑损伤急性期C-反应蛋白（CRP）与脑损伤程度、病情发展及预后的关系,以供临床参考。方法选择2012年10月~2013年10月青海省人民医院收治的颅脑损伤患者70例为研究对象,按格拉斯哥评分（GCS）将其分为轻型组（30例）、中型组（20例）、重型组（20例）。对患者颅脑损伤后2周内的脑脊液及血清水平进行测定和对比,分析CRP与脑损伤程度、病情发展及预后的关系。结果 70例颅脑损伤患者的CRP值均有一定程度的升高,其脑脊液及血清中CRP于3 d内达到高峰,轻型和中型组患者均于1周内恢复至正常水平,重型组患者CRP水平持续高峰可达2周,于1个月后恢复正常。颅脑损伤后1周内的血清CRP显著高于脑脊液CRP水平（P〈0.05）;颅脑损伤急性期CRP与程度相关,损伤程度越高,脑脊液及血清CRP水平越高,CRP可反映病情变化及预后。结论颅脑损伤急性期CRP为患者脑损伤程度的敏感指标,可作为判断病情进展、治疗效果以及预后的重要生化指标。
Objective To explore the correlation of C-reactive protein （CRP） with severity, progression and prognosis of brain injury in acute stage, offer a reference for clinical. Methods 70 patients with traumatic brain injury from October 2012 to October 2013 in Qinghai Provincial People＇s Hospital were selected as study objects, and they were divided into mild group （ 30 cases ） , medium group （ 20 cases ）, severe group （20 cases） according to Glasgow score （GCS）. 2 weeks after brain injury, the CRP cerebrospinal fluid and serum of patients were measured and compared, the correla-tion of CRP with severity, progression and prognosis were analyzed. Results CRP values of 70 patients with craniocere-bral injury had a certain degree of rise, the cerebrospinal fluid and serum CRP peaked within 3 days, all patients of light and medium group return to normal levels within 1 week, CRP levels of patients in heavy group was continue to rush up to 2 weeks, back to normal after 1 month. The level of CRP in serum was higher than that of the cerebrospinal fluid within 1 week after craniocerebral injury （P〈 0.05）. Acute craniocerebral injury CRP was associated with brain damage degree, the higher damage degree, the higher cerebrospinal fluid and serum level of CRP, CRP can reflect a-postasis and prognosis. Conclusion CRP is a sensitive indicator of the brain degree in patients with brain injury in a-cute stage, it can estimate the disease progression, treatment and prognosis.
出处
《中国医药导报》
CAS
2014年第25期43-46,共4页
China Medical Herald
基金
青海省基本科技计划项目(编号2013-Z-918)
关键词
颅脑损伤急性期
C-反应蛋白
脑损伤程度
病情发展
预后
Acute brain injury
C-reactive protein
Brain damage degree
Progression of disease
Prognosis
作者简介
马海峰（1970．10-），男，副主任医师；研究方向：脑科。
