摘要
近年来中药分析已经不再局限于仅仅提供分析方法,而更关注于包括本草学属性、药效成分和功效内涵等分析,即不仅分析物质的组成更要揭示其物质组成与功能的关系。近红外光谱分析技术以其独特的优势,目前在我国药物分析领域,特别是中药分析方面取得了较快发展。采用近红外光谱一方面可以全面地反映药材的整体信息,可用于鉴别和聚类分析。另一方面引入中药质量标志物的概念,通过筛选关键的药效成分,并通过化学计量学方法将光谱数据和其定量信息进行关联,可以实现对其中的多种药效成分同时进行定量分析。充分发挥近红外检测技术的优势,可以为中药材的质量快速评价提供更简便可靠的方法。该文从不同的侧面对近红外技术在中药材质量评价方面的进展和发展趋势进行了综述和讨论。
In recent years,the research object of traditional Chinese medicine（ TCM） analysis has not just been limited to the common analysis technology,but focused on the key relationship between chemical ingredients and traditional functions,including Chinese material medica（ CMM） attributes,chemical substance and biological function. Near infrared spectroscopy（ NIR） analysis technology,due to its unique advantages,has been developed rapidly in the field of pharmaceutical analysis,especially in the TCM analysis.NIRS can reflect the global chemical information comprehensively,and this holistic approach can be used for the identification and cluster analysis of CMM. On the other hand,inspiring by the concept of TCM quality markers（ Q-markers）,by means of the activity screening assay of the key components from the CMM,multiple bioactive components quantitation can be achieved by the NIRS combined with chemometrics. Taking the full advantage of the NIR technology,a simple and reliable method for the fast evaluation of the quality of TCMs can be provided. Therefore,the progress and trend of modern TCM quality evaluation by NIR are discussed and prospected in the present review.
作者
白钢
丁国钰
侯媛媛
姜民
高洁
BAI Gang DING Guo-yu HOU Yuan-yuan JIANG Min GAO Jie(College of Pharmacy, Nankai University, Tianjin 300350, China State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第19期3501-3505,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81373506
81430095
81374046)
关键词
中药材
质量控制
近红外技术
质量标志物
整合分析
Chinese material medica
quality evaluation
near infrared spectroscopy
Q-marker
integrated analysis
作者简介
[通信作者]白钢，博士，教授，博士生导师，研究方向为中药系统生物学与化学生物学，Tel：（022）2356792，E-mail：gangbai@nankai．edu．cn
