摘要
慢性肾病及其迁延进展所致的终末期肾病(ESRD)是危害人类健康、消耗大量卫生资源的重大慢性病。新近诸多研究证实,肠道菌群即'肠黏膜生物屏障',作为慢性肾脏病中'肾-肠轴'的中心环节,其结构功能改变及紊乱可能参与并导致了慢性肾功能衰竭的进展。中医药对肠道微生态的调节研究日益受关注,理论研究及临床、动物实验研究,均证实中药有助于调节肠道菌群,维持肠道微生态的平衡,并有望成为防治慢性肾功能衰竭进展的新干预靶点。立足中医讨论背景,文章从证候、药物、治疗、潜在新疗法等诸多方面论述中医肾病学与肠道微生态的相关性,为揭示肠道微生态的桥梁作用和中医本质提供一定的理论依据,并为转化医学的开展提供必要的理论基础和思路。
End-stage renal disease(ESRD)caused by chronic kidney disease(CKD)and its delayed progress is a major chronic disease that endangers human health and consumes a large number of health resources.Recent studies have confirmed that intestinal flora,the’intestinal mucosal membrane biological barrier’,is the central link of the’kidney-intestinal axis’in CKD.Its structural and functional changes and disorders may participate in and lead to the progress of chronic renal failure.The regulation of intestinal microecology by traditional Chinese medicine(TCM)has attracted more and more attention.Theoretical research,clinical and animal experiments have proved that TCM can help regulate intestinal microflora and maintain the balance of intestinal microecology,and it is expected to become a new intervention target for preventing and curing CRF progress.Based on the background of TCM discussion,this paper discussed the correlation between nephrology and intestinal microecology in TCM from many aspects,such as syndrome,medicine,treatment,a potential new therapy,etc.It provided a theoretical basis for revealing the bridge role of intestinal microecology and the essence of TCM and provided the necessary theoretical basis and ideas for the development of transformational medicine.
作者
裴明
杨洪涛
PEI Ming;YANG Hong-tao(Department of Nephrology,First Teaching Hospital of Tianjin University of TCM,Tianjin 300391,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2019年第6期2336-2341,共6页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金青年项目(No.81703860)
国家自然科学基金面上项目(No.81673909)
天津市科技计划项目(天津市中医内科临床医学研究中心,No.15ZXLCSY00020)~~
关键词
中医药
中医肾病学
肠道微生态
肾-肠轴
Traditional Chinese medicine
Nephrology of Chinese medicine
Gut microbiota
Kidney-gut axis
作者简介
通讯作者:杨洪涛,天津市西青区昌凌路88号天津中医药大学第一附属医院肾病科,邮编:300391,电话:022-27986578 E-mail:tjtcmht@126.com
