摘要
目的研究中药牛膝的三萜皂苷化学成分。方法采用大孔树脂、硅胶、ODS柱色谱分离纯化,经理化常数、光谱学方法鉴定结构。结果分离鉴定了2个酸性皂苷,结构分别为3-O-(3″-羧甲氧基-3-氧丙酮酸-3′-缩醛-4′-半缩酮)-β-D-吡喃葡萄糖醛酸基齐墩果酸-28-O-β-D-吡喃葡萄糖苷(牛膝皂苷Ⅲ,achyranthosideⅢ,1)和齐墩果酸3-O-(3″-羧甲氧基-3-氧丙酮酸-3′-缩醛-4′-半缩酮)-β-D-吡喃葡萄糖醛酸苷(牛膝皂苷Ⅳ,achyranthosideⅣ,2)。结论两者均为首次从牛膝中得到。
Aim Isolation and structural elucidation of the triterpenoid saponins of Achyranthes bientata B1. Methods Solvent extraction and column chromatography were used to isolate the triterpenoid saponins, and physico-chemical constants and spectroscopic analysis were employed for structural elucidation. Result Two saponins were isolated, and their structures were elucidated to be 3-O-（3″-carboxymethoxy-3-oxopyruvicacid-3′-acetal-4′-semi-ketal）-β-D-glucuronopyranosyl oleanolic acid 28-O-β-D-glucopyranoside（achyranthoside Ⅲ, 1 ） and oleanolic acid 3- O- （3″-carboxymethoxy-3-oxopyruvic acid-3′-acetal-4′-semi-ketal）-β-D-glu-curonopyranoside（achyranthoside Ⅳ, 2）. Conclusion They are both isolated from Achyranthes bientata B1. for the first time.
出处
《中国药物化学杂志》
CAS
CSCD
2005年第4期224-226,i0002,共4页
Chinese Journal of Medicinal Chemistry
基金
吉林省中医药局项目([2002]25号)
关键词
药物化学
成分分离
结构鉴定
色谱分析
波谱分析
牛膝
三萜皂苷
medicinal chemistry
constituent isolation
structural identification
chromatographic analysis
spectral analysis
Achyranthes bientata B1
triterpenoid saponins
作者简介
王广树（1963-），男（汉族），山东汶上人，教授，主要从事天然药物的研究，Tel：（0431）5648631。E-mail：wgs@jlu．edu．cn；杨晓虹（1954-），女（汉族），山东黄县人，教授，博士生导师，主要从事心血管药物的研究，Tel：（0431）5619706。
