摘要
伞形科前胡为我国传统的大宗中药材,主要含有香豆素类、有机酸类、甾醇类及挥发油等化学成分,其中香豆素类成分被公认为前胡的主要特征活性成分,在止咳、平喘、强心及心血管疾病防治等方面发挥着积极作用。随着后疫情环境下中医药被关注度的不断提升和中药研究的逐步深入,前胡药材及其香豆素类成分占据了一定的国内外市场并逐渐被开发利用。重点综述了中药前胡中香豆素类化学成分及其分析方法、药理作用的研究进展,旨在为前胡药材的质量评价、药理药效研究及前胡香豆素类成分的新药开发提供参考。
Peucedani Radix in the Umbelliferae family as one of the major traditional Chinese medicinal materials(TCMMs)contains coumarins,organic acids,sterols,volatile oils and other chemical components.Coumarins are recognized as the main bioactive constituents responsible for its effectiveness,and play a positive role in relieving cough and asthma,strengthening the heart function,as well as preventing and treating cardiovascular diseases.With the increasing attention paid to traditional Chinese medicine(TCM)in the post-pandemic environment and the progressive research on traditional Chinese herbal medicines(TCHMs),Peucedani Radix and the coumarin-like components have occupied certain domestic and international markets and are gradually being developed and exploited.In this paper,we reviewed the research progress of coumarin-like chemical components in Peucedani Radix,as well as their analytical methods and pharmacological effects,aiming to provide reference for the quality evaluation,pharmacological and efficacy research of Peucedani Radix and new drug development of coumarins in Peucedani Radix.
作者
王帅
石燕红
王瑞
胡世文
罗静
况刚
陈绍成
WANG Shuai;SHI Yanhong;WANG Rui;HU Shiwen;LUO Jing;KUANG Gang;CHEN Shaocheng(School of Biological&Chemical Engineering,Chongqing University of Education,Chongqing 400067,China;School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Institute of TCM International Standardization,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《上海中医药杂志》
2022年第9期89-99,共11页
Shanghai Journal of Traditional Chinese Medicine
基金
重庆市教委重大科技项目(KJZD-M201901601)
上海市科委“科技创新行动计划”技术标准项目(20DZ2200800)
关键词
前胡
香豆素
化学成分
质量评价
药理作用
中药研究
综述
Peucedani Radix
coumarins
chemical composition
quality evaluation
pharmacological effect
traditional Chinese herbal medicines research
review
作者简介
王帅,男,硕士研究生,主要从事中药资源开发与质量评价研究工作;通信作者:石燕红,副研究员,硕士研究生导师,E-mail:shiyhtcm@shutcm.edu.cn;通信作者:陈绍成,教授,硕士研究生导师,E-mail:csc19661@163.com
