摘要
为探究心脑血管疾病中成药的用药规律,以方剂用药为出发点,提取对于以脑卒中为代表的脑血管疾病和以冠状动脉疾病为代表的心血管疾病有共同治疗作用的核心药组,并分析其在治疗不同疾病时使用的一致性和差异性。该研究搜集主治功效分别为治疗脑血管疾病、心血管疾病和心脑血管疾病同治的市售中成药共388首,运用中医传承辅助平台分别进行"药频分析""配伍分析""网络分析",发现临床使用成药中药味的显性和隐性规律。综合3部分数据发现,丹参、川芎、红花、黄芪4味中药在治疗脑病、治疗心病、同时治疗脑心疾病中均有高使用频率,且配伍出现频繁。通过数据挖掘确认治疗脑心同发的血管性疾病的核心药物组合,揭示中医药心脑血管疾病用药规律的异同,为中成药临床合理使用提供了依据,并且为今后开发针对不同适应证的脑心疾病方剂组合指出新的方向。
To explore the regularity of traditional Chinese medicine(TCM) prescriptions for cardio-cerebrovascular diseases,the core drug groups with common therapeutic effects on cerebrovascular diseases represented by stroke and cardiovascular diseases represented by coronary artery disease were extracted,and their consistency and difference in the treatment of different diseases were analyzed.A total of 388 Chinese patent medicines were collected for the treatment of cerebrovascular diseases,cardiovascular diseases and cardio-cerebrovascular diseases.The dominant and recessive patterns of Chinese patent medicines in clinical use were found by 'frequency analysis','compatibility analysis' and 'network analysis' respectively.According to the findings of the three parts,Salviae Miltiorrhizae Radix et Rhizoma,Chuanxiong Rhizoma,Carthami Flos and Astragali Radix have a high frequency of use in the treatment of brain disease,heart disease and both,with frequent combined medication.Data mining confirmed the core drug combinations for the treatment of cerebral and cardiac vascular diseases,so as to reveal the similarities and differences in the drug use of Chinese medicine for these diseases,and provide a basis for the rational use of traditional Chinese medicine in clinical practice.This analysis also defines a new direction for the future development of prescription combinations for different indications of cerebral and cardiac diseases.
作者
高佳明
吕明
解微微
刘昕彦
赵步长
朱彦
GAO Jia-ming;LYU Ming;XIE Wei-wei;LIU Xin-yan;ZHAO Bu-chang;ZHU Yan(Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Research and Development Center of Traditional Chinese Medicine,Tianjin International Joint Academy of Biotechnology&Medicine,Tianjin 300457,China;Shangdong Buchang Pharmaceuticals Co.,Ltd.,Heze 274000,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2019年第1期193-198,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81873037)
国家重点研发计划项目(2018YFC1700232)
关键词
脑心同治
用药规律分析
中医传承辅助平台
cardio-cerebral vascular disease cotreatment
Chinese medicine prescription regularity
traditional Chinese medicine inheritance system
作者简介
通信作者:朱彦,博士,教授,博士生导师,研究方向为中药药理学,E-mail:yanzhu.harvard@icloud.com;高佳明,硕士研究生,E-mail:gaojmamazing@163.com
