摘要
基于中医传承辅助平台,对抗老年性痴呆方剂核心药物组合的筛选研究。方法:提取《中医方剂大辞典》中对老年性痴呆具有治疗作用的方剂,应用中医传承辅助平台(V 2.5)软件,录入方剂信息,构建数据库,使用软件的关联规则、改进的互信息法、复杂系统熵聚类等数据挖掘算法,分析治疗老年性痴呆的方剂中常用的药物、组合规则、显性及隐性药对、分析方与症的相关性及发现新方。结果:通过对102首抗老年性痴呆方剂所含药物的频次统计分析,得出抗老年性痴呆的常用药30个,其中人参、远志、茯苓、石菖蒲位居前4位;通过对其102首方剂的关联规则分析,得出使用频次较高的药对20个,其中人参与远志、远志与石菖蒲、人参与石菖蒲为常用药对的前3位;通过方症相关性规律发现《中医方剂大辞典》中治疗老年性痴呆方剂的核心药物组合与人参、远志、石菖蒲、茯苓相关性最大;通过改进的互信息法和复杂系统熵聚类的数据挖掘算法发现关联系数较高的隐性药对40个及演化新方2个。结论:《中医方剂大辞典》中治疗老年性痴呆方剂的核心组合成分与开心散吻合度最高,其方剂和组成药物对记忆力减退状况具有较为明确的治疗意义,挖掘得到的新方具有潜在的临床应用价值。
Objective： To study the screening methods of core herbal combinations of anti-Alzheimer prescriptions by using Traditional Chinese Medicine Inheritance System（ TCMIS）. Method： The traditional medical prescriptions for anti-Alzheimer in Dictionary of Chinese Medicine Prescriptions（ DCMP） were selected and TCMIS V2. 5 was used to input the prescription information and construct the database. The commonly used herbs,combination principles, Dominance Recessive herb pairs and the correlations between prescriptions and symptoms were analyzed and new prescriptions were developed with data mining methods such as association rules,improved mutual information method and complex system entropy clustering. Result： The 30 commonly used herbs were concluded based on the statistic frequency analysis of 102 anti-Alzheimer prescriptions. Ginseng Radix et Rhizoma,Polygalae Radix,Acori Poria and Tatarinowii Rhizoma ranked top four in frequency. The 20 commonly used herb pairs were concluded based on the association rules analysis of 102 anti-Alzheimer prescriptions. Ginseng Radix et Rhizoma-Polygalae Radix, Polygalae Radix-Tatarinowii Rhizoma, and Ginseng Radix et Rhizoma and Tatarinowii Rhizoma ranked top three among the commonly used herb pairs. In accordance with the correlations between prescriptions and symptoms,the core herbal combinations for anti-Alzheimer prescriptions in DCMP were greatly correlated with Ginseng Radix et Rhizoma,Polygalae Radix,Tatarinowii Rhizoma and Acori Poria. The 40 new core combinations and 2 newly developed prescriptions were concluded based on improved mutual information method and complex system entropy clustering in 102 prescriptions for anti-Alzheimer. Conclusion： The ingredients in core combinations of anti-Alzheimer prescriptions were highly coincided with those in Kaixin San in DCMP,with clear treatment significance for memory loss. The two newly developed prescriptions for antiAlzheimer found by TCMIS V2. 5 have some clinical value.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第7期223-228,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81473375
81273629)
山西省基础研究计划项目(2014011047-2)
山西省回国留学人员科研项目(2013-134)
山西中医学院2011计划培育项目(PY2011-4)
关键词
《中医方剂大辞典》
老年性痴呆
中医传承辅助平台
开心散
Dictionary of Chinese Medicine Prescription
Alzheimer disease
Traditional Chinese Medicine Inheritance System V2.5
Kaixin San
作者简介
刘根，硕士，从事中医药防治脑病的基础和临床研究，Tel：15103407449，E—mail：18636909449@163．com
[通讯作者]贺文彬，博士，教授，硕士生导师，从事中医脑藏象学研究，Tel：0351-3179977，E-mail：hewb@sxtcm.com
