摘要
目的探讨白细胞介素17(interleukin 17,IL-17)信使RNA(messenger RNA,mRNA)和前列腺素E2(prostaglandin E2,PGE2)mRNA在口腔扁平苔藓(oral lichen planus,OLP)患者中的表达水平及与临床中疼痛程度的关系,并观察免疫功能各指标的变化。方法回顾性分析62例南阳医学高等专科学校第一附属医院2022年1月—2023年10月收治的口腔扁平苔藓患者的临床资料,根据患者口腔组织是否出现糜烂分为糜烂组和非糜烂组,根据患者疼痛程度分为无疼痛组、轻度疼痛组、中度疼痛组和重度疼痛组,比较不同组别患者的IL-17 mRNA与PGE2 mRNA水平,分析口腔扁平苔藓患者IL-17 mRNA与PGE2 mRNA水平的相关性及IL-17 mRNA、PGE2 mRNA水平与患者疼痛度的相关性,评价免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulin M,IgM)和免疫球蛋白A(immunoglobulin A,IgA)等免疫功能各指标在糜烂组和无糜烂组中差异。结果口腔扁平苔藓患者中,组织糜烂患者的IL-17 mRNA与PGE2 mRNA水平分别为(45.52±7.35)、(27.55±6.10),均高于无糜烂组,差异有统计学意义(P<0.05);随着疼痛度加重,口腔扁平苔藓患者的IL-17 mRNA与PGE2 mRNA水平逐渐提高,差异有统计学意义(P<0.05);相关性分析显示,扁平苔藓患者IL-17 mRNA与PGE2 mRNA水平及IL-17 mRNA、PGE2 mRNA水平与患者疼痛度均呈现出明显正相关性(r=0.511、0.705、0528,P<0.05);无糜烂组IgG、IgA、IgM水平分别为(1.80±0.52)g/L、(2.20±0.70)g/L、(14.00±1.28)g/L,均高于糜烂组,差异有统计学意义(P<0.05)。结论口腔扁平苔藓组织糜烂的发生是免疫力降低的象征,会进一步升高IL-17 mRNA与PGE2 mRNA水平,扁平苔藓患者IL-17 mRNA与PGE2 mRNA水平呈现明显正相关,同时IL-17 mRNA、PGE2 mRNA水平与患者疼痛度也呈现出明显正相关性。
Objective To investigate the expression levels of interleukin-17(IL-17)messenger RNA(mRNA)and prostaglandin E2(PCE2)mRNA in oral lichen planus(OLP)patients and their clinical significance in relation to the de-gree of clinical pain,and to observe the changes of immune function indexes.Methods The clinical data of 62 oral lichen planus patients admitted to the First Affiliated Hospital of Nanyang Medical College from January 2022 to October 2023 were retrospectively analyzed.Patients were classified into the erosion group and the non-erosion group based on whether there was erosion in their oral tissues.According to the degree of pain,they were divided into the painless group,the mild pain group,the moderate pain group and the severe pain group,and IL-17 mRNA and PCE2 mRNA levels were compared in different groups.The correlation between IL-17 mRNA and PCE2 mRNA levels in oral lichen planus patients and the correlation between IL-17 mRNA and PGE2 mRNA levels and the pain degree of patients were analyzed.The difference of immune function indexes such as immunoglobulin G(IgG),immunoglobulin M(IgM)and immunoglobulin A(IgA)in erosion group and non-erosion group were evaluated.Results In oral lichen planus patients,the levels of IL-17 mRNA and PGE2 mRNA in tissue erosion patients were(45.52±7.35)and(27.55±6.10),respectively,which were higher than those in non-erosion group(P<0.05).The levels of IL-17 mRNA and PGE2 mRNA in oral lichen planus patients increased with the severity of pain(P<0.05).Correlation analysis showed that IL-17 mRNA and PGE2 mRNA levels,and IL-17 mRNA and PGE2 mRNA levels were significantly positively correlated with pain degree in patients with lichen planus(r=0.511,0.705,0528,P<0.05).The levels of IgG,IgA and IgM in the erosion-free group were(1.80±0.52)g/L,(2.20±0.70)g/L and(14.00±1.28)g/L,respectively,which were higher than those in the erosion-free group(P<0.05).Conclusion The occurrence of oral lichen planus tissue erosion is a symbol of decreased immunity,and will further increase the levels of IL-17 mRNA and PGE2 mRNA,the levels of IL-17 mrna and PGE2mRNA in patients with lichen planus showed a significant positive correlation.Meanwhile,the levels of IL-17 mrna and PGE2mRNA also showed a significant positive correlation with the pain degree of the patients.
作者
王琛霓
李海朋
黄莹莹
WANG Chen-ni;LI Hai-peng;HUANG Ying-ying(Department of Stomatology,the First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan 473000,China)
出处
《医药论坛杂志》
2025年第15期1640-1643,共4页
Journal of Medical Forum
