摘要
目的:利用数据挖掘方法探讨银翘散的现代临床应用。方法:通过检索中国知网(CNKI)中运用银翘散治疗有效的临床研究文献,根据纳入排除标准,收集符合的数据,建立银翘散临床研究文献信息数据库,对银翘散的剂量组成、病证应用、主治证型等方面进行分析,通过R语言对银翘散加味药物进行频数统计分析、关联规则分析并进行可视化展示。结果:共纳入260篇银翘散临床研究文献,其中汤剂242篇,颗粒剂18篇。确定了银翘散单次应用剂量及各药物的临床单日所用剂量;银翘散治疗的疾病共88种,尤以儿科、呼吸科疾病为主,其中小儿手足口病最多,次之是上呼吸道感染;主治证型中含有风、热、络等因素,与肺卫、肺、胃等病位相关,以风热闭肺证为主;主要配伍方剂种类为解表剂、清热剂、祛湿剂,与银翘散配伍最多的分别是麻杏石甘汤、普济消毒饮、藿朴夏苓汤,分别常用于治疗小儿肺炎、扁桃体炎、小儿手足口病;配伍的中药按关联强弱依次为苦杏仁、黄芩、蝉蜕、石膏、桑叶,得出配伍苦杏仁、蝉蜕更好改善小儿肺炎、上呼吸道感染等疾病所引起的呼吸道症状,配伍黄芩、石膏、桑叶尤其对与感染有关的疾病效果好。结论:银翘散能有效治疗儿科、呼吸科疾病,病位在肺卫、肺、胃,以风热闭肺证为主,可配伍苦杏仁、黄芩、蝉蜕、石膏、桑叶等。
Objective:To explore the modern clinical application of Yinqiao Powder(银翘散)using data mining methods.Methods:By retrieving the clinical research literature on the effective treatment with Yinqiao powder in the China National Knowledge Infrastructure(CNKI),according to the inclusion and exclusion criteria,the eligible data were collected to establish a literature information database of clinical research on Yinqiao Powder.The dosage composition,application of disease-syndrome,main syndromes treated by Yinqiao Powder were analyzed.Frequency statistical analysis,and association rule analysis of the additional drugs in Yinqiao Powder were carried out through R language and visualized.Results:A total of 260 clinical research literatures on Yinqiao Powder were included,among which 242 were about decoctions and 18 were about granules.The single dosage of Yinqiao Powder and the daily clinical dosage of each drug were determined.Yinqiao Powder was used to treat 88 kinds of diseases,especially those in pediatrics and respiratory department.Hand-foot-mouth disease in children was the most common,followed by upper respiratory tract infection.The main indicated syndromes contained factors such as wind,heat,collaterals,etc.,and were related to the disease locations of lung-defense,lung,and stomach,with the syndrome of wind-heat obstructing lung as the main one.The main types of compatible formulas were formulas for relieving exterior syndrome,formulas for clearing heat,formulas for expelling dampness.The formulas most commonly combined with Yinqiao Powder were Maxing Shigan Decoction(麻杏石甘汤),Puji Xiaodu Drink(普济消毒饮),and Huopu Xiaoling Decoction(藿朴夏苓汤),which were commonly used to treat pediatric pneumonia,tonsillitis,and hand-foot-mouth disease in children respectively.The Chinese medicinals used in combination,in the order of the strength of association,were Kuxingren(Armeniacae Semen Amarum),Huangqin(Scutellariae Radix),Chantui(Cicadae Periostracum),Shigao(Gypsum),and Sangye(Mori Folium).It was found that the combination with Kuxingren and Chantui could better improve the respiratory symptoms caused by diseases such as pediatric pneumonia and upper respiratory tract infection,and the combination with Huangqin,Shigao,and Sangye was especially effective for diseases related to infection.Conclusions:Yinqiao Powder can effectively treat diseases in pediatrics and respiratory department.The disease locations are in the lung-defense,lung,and stomach,with the syndrome of wind-heat obstructinging lung being the main one.It can be combined with Kuxingren,Huangqin,Chantui,Shigao,and Sangye,etc.
作者
余新波
刘城鑫
蓝婉宁
江勇
詹少锋
YU Xinbo;LIU Chengxin;LAN Wanning;JIANG Yong;ZHAN Shaofeng(First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Shenzhen 518000,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)
出处
《山东中医药大学学报》
2025年第4期461-468,共8页
Journal of Shandong University of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(编号:82274418)
广东省研究生教育创新计划项目(编号:2022ANLK025)
广东省中医药科研项目(编号:20231169)
深圳市“医疗卫生三名工程”项目(编号:SZZYSM202206013)
深圳市宝安区医疗卫生科研项目(编号:2023JD107)。
关键词
银翘散
风热闭肺证
儿科
呼吸科
苦杏仁
蝉蜕
R语言
数据挖掘
Yinqiao Powder(银翘散)
syndrome of wind-heat obstructing lung
pediatrics
respiratory department
Kuxingren(Armeniacae Semen Amarum)
Chantui(Cicadae Periostracum)
R language
data mining
作者简介
余新波,住院医师,研究方向:中医药防治呼吸系统疾病;通信作者:詹少锋,主任中医师,主要从事中医药防治呼吸系统疾病研究。邮箱:zsfstone@126.com。
