摘要
慢性疼痛和睡眠障碍是临床普遍发生且常同时共存的问题,严重影响患者的健康状况,给社会带来巨大的医疗负担。临床研究提示,慢性疼痛可导致睡眠障碍,睡眠障碍又会加剧慢性疼痛或诱发新的疼痛,形成恶性循环。文章综述了慢性疼痛与睡眠障碍的双向作用及其涉及的神经递质紊乱、免疫失衡、氧化应激和神经环路等机制,以期为防治睡眠障碍‑慢性疼痛共病提供新的诊疗策略。
Chronic pain and sleep disorders are common clinical problems that often coexist,severely affecting patients'health and imposing a significant medical burden on society.Clinical studies suggest that chronic pain can lead to sleep disorders,while sleep disorders can exacerbate chronic pain or trigger new pain,creating a vicious cycle.This review comprehensively examines the bidirectional relationship between chronic pain and sleep disorders,elucidating the underlying mechanisms such as neurotransmitter imbalances,immune dysregulation,oxidative stress,and neural circuitry alterations,aiming to provide new diagnostic and therapeutic strategies for the management of comorbid sleep disorders and chronic pain.
作者
涂洪琴
郑智滢
顾小萍
张伟
Tu Hongqin;Zheng Zhiying;Gu Xiaoping;Zhang Wei(Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China;Department of Anesthesiology,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《国际麻醉学与复苏杂志》
2025年第5期511-516,共6页
International Journal of Anesthesiology and Resuscitation
关键词
慢性疼痛
睡眠障碍
神经递质
免疫失衡
氧化应激
Chronic pain
Sleep disorder
Neurotransmitter
Immune imbalance
Oxidative stress
作者简介
通信作者:张伟,Email:zhangwei2008@njmu.edu.cn。
