摘要
“郁”是肿瘤演变过程中的重要状态,贯穿肿瘤发生发展全程,但既往研究并未诠释郁与肿瘤演变各阶段的内在关联。结合临床实践,针对肿瘤各阶段“郁”的关键病机不同而分期论治,提出郁毒理论并阐释其内涵,基于“木、火、土、金、水”五郁诠释肿瘤发展不同阶段郁毒的病因病机,包括癌前阶段木郁而病生、术后阶段金郁而症作、辅助治疗阶段火郁而疡起、进展阶段土郁而毒传、晚期阶段水郁而坏证;并提出木郁达之以逆势、金郁泄之以平症、火郁发之以退疡、土郁夺之以截舍、水郁折之以生息的治则治法,为中医药从郁毒角度认识与辨治恶性肿瘤提供理论依据。
"Stagnation"is an important pathological state in the development and progression of malignant tumors.However,its intrinsic connection with different stages of tumor evolution has not been clearly elucidated in previous studies.Drawing on clinical practice,this paper proposes the theory of stagnant toxin,emphasizing stage-specific pathogenesis and differentiated treatment strategies for tumors based on the varying manifestations of stagnation at each phase.The theory interprets the pathogenesis of stagnant toxin across the stages of tumor development through the five elements"wood,fire,earth,metal,and water"corresponding respectively to wood stagnation in the precancerous stage,metal stagnation in the postoperative phase,fire stagnation during adjuvant therapy,earth stagnation in the progressive stage,and water stagnation in the advanced stage.Each type of stagnation reflects a distinct pathogenic mechanism,such as wood stagnation giving rise to disease,metal stagnation inducing residual symptoms,fire stagnation resulting in ulceration,earth stagnation spreading toxin transmission,and water stagnation leading to critical deterioration.Accordingly,the treatment principles include guiding wood stagnation with counterflow,dispersing metal stagnation to harmonize symptoms,venting fire stagnation to regress ulcers,depleting earth stagnation to block progression,and controlling water stagnation to preserve vitality.This theoretical framework offers a traditional Chinese medicine perspective for understanding and treating malignant tumors based on the concept of stagnant toxin.
作者
曹璐畅
高瑞珂
徐曼曼
朱潇雨
朱广辉
李杰
CAO Luchang;GAO Ruike;XU Manman;ZHU Xiaoyu;ZHU Guanghui;LI Jie(Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing,100053)
出处
《中医杂志》
北大核心
2025年第10期1000-1006,共7页
Journal of Traditional Chinese Medicine
基金
中央高水平中医医院临床科研业务费(HLCMHPP2023097,HLCMHPP2023001)
中国中医科学院科技创新工程重点协同攻关项目(CI2023C012YL)。
关键词
肿瘤
郁毒
木郁
火郁
土郁
金郁
水郁
tumor
stagnant toxin
wood stagnation
fire stagnation
earth stagnation
metal stagnation
water stagnation
作者简介
通讯作者:李杰,drjieli2007@126.com。
