摘要
目的 分析河南省1~79岁人群乙型肝炎(乙肝)血清流行率。方法 2023年8-11月在河南省18个省辖市选取29个村/社区的1~79岁人群开展问卷调查并采集血清标本,采用酶联免疫吸附试验检测乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)和乙肝核心抗体(Hepatitis B core antibody,HBcAb),分析血清流行率。结果 共纳入调查对象11 883例,HBsAg、HBsAb、HBcAb阳性率分别为1.24%、69.49%、25.40%,标化阳性率分别为1.98%、62.62%、32.28%。各年龄组HBsAg、HBsAb、HBcAb阳性率分别在0.23%~3.75%、46.92%~88.07%、16.30%~59.05%之间(χ^(2)=149.73,P<0.001;χ^(2)=1 146.45,P<0.001;χ^(2)=732.02,P<0.001);其中1~19岁、20~79岁各年龄组HBsAg阳性率分别在0.23%~0.56%、1.20%~3.75%之间,15~19岁、55~59岁HBsAb阳性率最低,分别为46.92%、53.36%。结论 2023年河南省1~79岁人群乙肝感染总体处于低流行水平,<19岁人群感染率低,易感高峰年龄为15~19岁和55~59岁。需继续保持儿童乙肝疫苗高水平接种率,探讨高易感人群乙肝疫苗加强或补充免疫的必要性。
Objective To analyze hepatitis B seroprevalence among people aged 1-79 years in Henan province.Methods We selected 1-79-year-olds from 29 villages/communities in 18 prefectures of Henan for a questionnaire-based survey,and obtained serum samples between August and November 2023.We tested for hepatitis B surface antigen(HBsAg),surface antibody(HBsAb),and core antibody(HBcAb)using enzyme-linked immunosorbent assay to determine seroprevalences.Results A total of 11883 subjects were included,in which HBsAg,HBsAb,and HBcAb positivity rates were 1.24%,69.49%,and 25.40%(adjusted:1.98%,62.62%,and 32.28%),respectively.HBsAg,HBsAb,and HBcAb positivity by age group ranged from 0.23%to 3.75%,46.92%to 88.07%,and 16.30%to 59.05%(χ^(2)=149.73,P<0.001;χ^(2)=1146.45,P<0.001;χ^(2)=732.02,P<0.001).HBsAg positivity ranges among 1-19-and 20-79-year-olds were 0.23%to 0.56%and 1.20%to 3.75%.HBsAb positivity rates for 15-19-and 55-59-year-olds s were the lowest at 46.92%and 53.36%.Conclusions The prevalence of hepatitis B infection generally remained low among people aged 1-79 years in Henan in 2023,particularly among<19-year-olds.Susceptibility peaked in 15-19-and 55-59-year-olds.It is necessary to continuously maintain high coverage with childhood hepatitis B vaccination and explore the necessity of booster doses or supplementary hepatitis B vaccination for highly susceptible populations.
作者
豆巧华
刘倩
马雅婷
杨建辉
吕宛玉
赵升
张璐
李军
肖占沛
王文慧
丁宝龙
唐玉婷
丰达星
孔江南
僧明华
郭永豪
张延炀
Dou Qiaohua;Liu Qian;Ma Yating;Yang Jianhui;Lv Wanyu;Zhao Sheng;Zhang Lu;Li Jun;Xiao Zhanpei;Wang Wenhui;Ding Baolong;Tang Yuting;Feng Daxing;Kong Jiangnan;Seng Minghua;Guo Yonghao;Zhang Yanyang(Henan Prorincial Center for Disease Control and Prevention,Zhengzhou 450016,Henan,China;Henan Provincial Key Laboratory of Immunication and Preventire Medicine,Zhengzhou 450016,Henan,China;School of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China)
出处
《中国疫苗和免疫》
北大核心
2025年第2期189-194,共6页
Chinese Journal of Vaccines and Immunization
基金
河南省医学科技攻关计划联合共建项目(LHGJ20240623)
河南省自然科学基金项目(222300420466)
中国肝炎防治基金会中国乙肝防控科研基金项目(YGFK20240112)。
作者简介
通信作者:郭永,Email:cdcgyh@163.com第一作者:豆巧华,Email:2955405287@qq.com。
