摘要
目的探究6年来济南地区无偿献血人群经血传播病原体感染状况,为今后无偿献血人群招募及血液筛查策略的更新和完善提供合理的数据支撑。方法2016年~2021年,山东省血液中心对653135例无偿献血者的标本进行了乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)、人体缺陷免疫病毒(HIV)、梅毒螺旋体(TP)ELISA双试剂血清学标记的检测。其中,初筛抗艾滋病病毒反应性标本送至济南市疾病预防控制中心,采用蛋白免疫印迹法开展确证试验;统计分析济南地区无偿献血人群经血传播病原体血清学阳性率及其在不同人群中的流行趋势。结果济南地区无偿献血人群经血传播病原体血清学总阳性率为0.37%,其中HBsAg、抗HCV、抗HIV、抗TP阳性率分别为0.14%,0.05%,0.01%,0.17%.HIV阳性率保持相对稳定(P>0.05),而HBV、HCV的流行率总体呈下降趋势(P<0.05),其中TP阳性率变化显著(P<0.01)。年龄较高、文化程度较低、初次献血人群经血传播病原体阳性率相对较高。结论2016年~2021年济南地区无偿献血人群经血传播病原体阳性率总体处于较低水平,但其感染风险仍然存在,加强固定献血者的招募和提高实验室血液筛查技术可以有效降低经血传播病原体感染风险。
Objective To investigate the status of transfusion-transmissible infection among voluntary blood donors in Jinan in the past six years,in order to provide reasonable data support for the recruitment of blood donation and the update of blood screening strategies in the future.Methods From 2016 to 2021,Shandong Blood Center performed hepatitis B virus,hepatitis C virus,HIV virus,and syphilis spiral ELISA double detection of reagent serum symbols.Among them,the first screen resistance-HIV reactive specimen was sent to Jinan Center for Disease Control and Prevention to conduct confirmation experiments by using the protein immunization marks.The prevalence of transfusion-transmissible infection was calculated and the trend of disease was analyzed under different demographic groups.Results The total positive rate of transfusion-transmissible infection serum science in Jinan area was 0.37%,among which the positive rates of HBsAg,anti-HCV,anti-HIV and anti-TP were 0.14%,0.05%,0.01%and 0.17%,respectively.The positive rate of HIV remained relatively stable(P>0.05),while the popularity of HBV and HCV generally showed a downward trend(P<0.05),and the positive rate of TP had a significant change(P<0.01).Those of advanced age and low education levels,and first-time blood donors were high-positive.Conclusion From 2016 to 2021,the positive rate of blood donation in Jinan was generally at a low level,but the risks still existed.Strengthening the recruitment and improvement of laboratory blood screening technologies for fixed blood donors can help to effectively reduce the risk of raw infection of the pathogenic infection of menstrual blood.
作者
陈萍
CHEN Ping(Blood Center of Shandong Province,Jinan 250014,China)
出处
《潍坊医学院学报》
2023年第3期178-181,242,共5页
Acta Academiae Medicinae Weifang
基金
山东省医药卫生科技发展计划(项目编号:2019WS541)
作者简介
陈萍(1982年~),女,主治医师,硕士学位。主要研究方向:血液传播疾病的预防控制工作。
