摘要
勃起功能障碍(ED)是男性生殖系统损伤最常见的表现之一,也是一种常见的糖尿病(DM)并发症,与患者的生活质量、性伴侣关系、家庭稳定密切相关,更是许多躯体疾病的早期预警信号。随着糖尿病发病率增高,糖尿病性勃起功能障碍(DMED)发病率将随之增高。目前ED药物治疗效果欠佳,DMED更为难治,因此寻求有效且安全的药物是目前亟待解决的临床问题。近年来,诸多研究证明中药可通过调控相关信号通路,从而减轻氧化应激、抑制炎症反应、调控细胞自噬等,达到改善DMED的目的,具有多途径、多靶点、多环节、疗效显著的优势。磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、一氧化氮-环磷酸鸟苷(NO/cGMP)、Ras同源基因家族成员A(RhoA)/Rho、核因子E_(2)相关因子2(Nrf2)、丝裂原活化蛋白激酶(MAPK)、腺苷酸活化蛋白激酶(AMPK)、蛋白激酶C(PKC)通路等多条信号通路介导了DMED的发生发展,但目前尚缺乏相关的总结性记载,基于此,该文通过查阅近年来国内外相关文献,综述上述相关信号通路在DMED发生发展中的作用及中药调控相关信号通路治疗DMED的研究进展,以期为进一步的临床诊疗、基础研究及药物开发提供新的思路与参考。
Erectile dysfunction(ED)is one of the most common manifestations of male reproductive system damage,and it is also a common complication of diabetes mellitus(DM).ED is closely related to the patient’s quality of life,sexual partner relationship,and family stability.In addition,it is an early warning signal for many physical diseases.As the incidence of DM keeps growing,the incidence of diabetes mellitus-induced erectile dysfunction(DMED)increases accordingly.Currently,drug treatment for ED presents limited effects,and the treatment of DMED is more difficult.Therefore,developing effective and safe drugs is a clinical problem that needs to be solved urgently.Recent studies have proved that traditional Chinese medicine(TCM)can alleviate oxidative stress,reduce inflammation,and modulate autophagy by regulating multiple signaling pathways,thus ameliorating DMED,showing definite therapeutic effects via multiple pathways,targets,and links.Multiple signaling pathways such as phosphatidylinositol-3-kinase/protein kinase B(PI3K/Akt),nitric oxide(NO)-cyclic guanosine monophosphate(cGMP),Ras homolog family member A(RhoA)/Rho,nuclear factor erythroid 2-related factor 2(NRF2),mitogen-activated protein kinase(MAPK),adenosine monophosphate-activated protein kinase(AMPK),and protein kinase C(PKC)mediate the occurrence and development of DMED,while there is still a lack of conclusive records.By reviewing relevant articles published in recent years,this paper summarizes the role of the above-mentioned signaling pathways in the occurrence and development of DMED and the research progress in TCM treatment of DMED via regulation of related signaling pathways.This review is expected to provide new ideas and references for further clinical diagnosis and treatment,basic research,and drug development.
作者
刘银霞
杨丹
LIU Yinxia;YANG Dan(Guizhou Medical University,Guiyang 550000,China;Department of Surgery,Guizhou Medical University,Guiyang 550000,China)
出处
《中国实验方剂学杂志》
北大核心
2025年第5期339-346,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
贵州省科学技术厅项目[黔科合LH字(2014)7087]
2018贵州省大学生创新创业训练资助项目(2018520365)。
关键词
糖尿病
勃起功能障碍
中药
信号通路
研究进展
diabetes mellitus
erectile dysfunction
traditional Chinese medicine
signaling pathway
research progress
作者简介
第一作者:刘银霞,在读硕士,从事男性不育研究,E-mail:1171976917@qq.com;通信作者:杨丹,副教授,从事男性不育研究,E-mail:yangdan@gmc.edu.cn。
