摘要
糖尿病性勃起功能障碍(DMED)是伴发于血糖控制不佳的性功能障碍疾病,是临床最常见的器质性ED,而神经系统的病变是其发生过程中最主要的一个病理机制。铁死亡途径是一种新的自噬依赖性细胞死亡形式,参与了多种疾病的发生和发展,且与神经细胞的死亡有密切相关性。研究证实铁死亡途径参与了DMED的神经调节机制,可作为DMED治疗的重要依据。有研究表明部分中药提取物可以抑制神经细胞的铁死亡途径,本文从中药提取物通过抑制神经细胞的铁死亡途径,对DMED的神经保护机制进行总结,为今后临床治疗该病奠定理论基础。
Diabetic ED(DMED)is a sexual dysfunction disease accompanied by poor blood sugar control,which is a most common organic ED clinically,with the lesions of the nervous system as the most important pathological mechanism in the process of its occurrence.Ferroptosis is a new form of autophagy-dependent cell death involved in the development and progression of a variety of diseases and closely related to the death of nerve cells.The ferroptosis pathway has been conformed to be involved in the mechanism of neuromodulation of DMED,which can be used as an important basis for the treatment of the disease.Studies have shown that some herbal extracts can inhibit the ferroptosis pathway of nerve cells.This review summarizes the neuroprotective mechanism of traditional Chinese medicine extracts in the treatment of DMED by inhibiting the ferroptosis pathway of nerve cells,and provides a theoretical foundation for future clinical treatment of the disease.
作者
徐子龙(综述)
马紫阳(综述)
张培海(审校)
XU Zi-long;MA Zi-yang;ZHANG Pei-hai(Department of Urology and Andrology/Key Laboratory of Sichuan Province for TCM Regulation of Metabolic Diseases,Hospital of Chengdu University of Chinese Medicine,Chengdu,Sichuan 610075,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2022年第11期1049-1053,共5页
National Journal of Andrology
关键词
铁死亡途径
糖尿病性勃起功能障碍
神经保护
中药提取物
ferroptosis pathway
diabetic erectile dysfunction
neuroprotection
traditional Chinese medicine extract
作者简介
徐子龙(1999-),男,湖北武汉市人,硕士研究生,从事泌尿及生殖专业;通讯作者:张培海,Email:zhangpeihai@126.com
