摘要
目的:探讨高频重复经颅磁刺激(rTMS)对慢性精神分裂症患者阴性症状、脑源性神经营养因子(BDNF)和血管内皮生长因子(VEGF)的影响,并分析患者阴性症状的改善和BDNF、VEGF变化的关系。方法:纳入2018年1月至2022年10月在温州医科大学附属康宁医院住院的慢性精神分裂症患者60例,根据住院号随机分为真刺激组30例和伪刺激组30例,在治疗前和治疗24周后采用阴性阳性症状量表(PANSS)评定患者的精神症状,同时检测血清BDNF和VEGF。结果:经过24周的治疗,真刺激组PANSS阳性症状分、阴性症状分低于伪刺激组,血清BDNF、VEGF水平高于伪刺激组(P<0.05);真刺激组阳性症状分差值、阴性症状分差值、血清BDNF差值和VEGF差值高于伪刺激组(P<0.05)。Pearson相关分析显示真刺激组血清BDNF差值与PANSS阴性症状分差值呈显著正相关(r=0.478,P<0.01)。线性回归分析结果显示不同血清BDNF差值对阴性症状分差值的影响有统计学差异(β=0.457,t=2.536,P<0.05)。结论:高频rTMS可能通过提高慢性精神分裂症患者血清BDNF水平改善其阴性症状。
Objective:To investigate the impact of high-frequency repetitive transcranial magnetic stimulation(rTMS)on negative symptoms,brain-derived neurotrophic factor(BDNF),and vascular endothelial growth factor(VEGF)in patients with chronic schizophrenia,and to further analyze the relationship between negative symptom improvement and changes in BDNF and VEGF levels during the treatment of rTMS.Methods:Sixty patients with chronic schizophrenia hospitalized in the Affiliated Kangning Hospital of Wenzhou Medical University from January 2018 to October 2022 were recruited and randomly assigned,according to their serial number,into a real stimulation group and a sham stimulation group with 30 cases in each.The positive and negative syndrome scale(PANSS)was used to assess the mental symptoms of the patients before treatment and 24 weeks after treatment,and meanwhile serum BDNF and VEGF were detected.Results:After 24 weeks of treatment,the real stimulation group exhibited lower scores of positive and negative symptom and higher serum levels of BDNF and VEGF(P<0.05),compared with sham stimulation group.The real stimulation group demonstrated significantly higher score difference of positive and negative symptom,as well as serum BDNF and VEGF levels,compared with the sham stimulation group(P<0.05).Pearson correlation analysis revealed that there was significant positive correlation between the changes in serum BDNF levels and negative symptom scores in the real stimulation group (r=0.478, P<0.01) after treatment. In addition, linear regression analysis demonstrated the difference of serum BDNF levels had a statistically significant effect on the difference of symptom scores (β=0.457, t=2.536, P<0.05) in real stimulation group after treatment. Conclusion: The improvement of negative symptoms in patients with chronic schizophrenia following high-frequency rTMS may be associated with changes in serum BDNF levels.
作者
陈伊宁
刘家洪
叶涵
连逸辰
施苏密
杨志颖
陈楚楚
孙孝笑
潘安乐
CHEN Yining;LIU Jiahong;YE Han;LIAN Yichen;SHI Sumi;YANG Zhiying;CHEN Chuchu;SUN Xiaoxiao;PAN Anle(Department of Psychiatry,the Affiliated Kangning Hospital of Wenzhou Medical University,Zhejiang Provincial Clinical Research Center for Mental Disorder,Wenzhou 325000,China;School of Psychiatry,Wenzhou Medical University,Wenzhou 325035,China)
出处
《温州医科大学学报》
CAS
2024年第4期302-306,共5页
Journal of Wenzhou Medical University
基金
温州市基础性科研项目(Y20220839)。
关键词
精神分裂症
阴性症状
重复经颅刺激
脑源性神经营养因子
血管内皮生长因子
schizophrenia
negative symptoms
transcranial magnetic stimulation
brain-derived neurotrophic factor
vascular endothelial growth factor
作者简介
第一作者:陈伊宁,住院医师,Email:727719262qq.com;通信作者:潘安乐,副主任医师,Email:3662122380qq.com。
