摘要
目的探讨稳定期精神分裂症患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)水平及其与临床症状的关系。方法纳入稳定期精神分裂症患者75例(患者组)和健康对照40名(对照组),采用流式多重蛋白分析技术(cytometric bead array,CBA)检测外周血清VEGF水平,采用阳性与阴性症状量表(positive and negative symptom scale, PANSS)评定患者临床症状。结果患者组VEGF水平较健康对照组低[M(QL,QU):3.77(2.61, 5.14)pg/mL vs. 6.21(4.37,11.16)pg/mL],差异有统计学意义(P<0.01);不同性别、是否吸烟、是否有精神疾病家族史患者之间血清VEGF的水平差异均无统计学意义(P>0.05);患者组血清VEGF水平与性别、年龄、受教育年限、首次发病年龄、首次住院年龄、总病程、用药剂量折合氯丙嗪剂量均无统计学相关性(P>0.05)。患者组VEGF水平与PANSS总分(r=-0.27,P=0.03)、阴性症状分(r=-0.25,P=0.04)、反应缺乏症状群分(r=-0.26,P=0.02)呈负相关。结论稳定期精神分裂症患者血清VEGF水平低于健康对照,患者血清VEGF水平与临床症状严重程度存在一定联系。
Objective To investigate the level of serum vascular endothelial growth factor (VEGF) in stable schizophrenia patients, and to explore the relationship between serum VEGF level and clinical symptoms. Methods Seventy-five patients with stable schizophrenia and 40 healthy controls were enrolled. The levels of serum VEGF were detected by flow multiplex protein analysis. The clinical symptoms of patients were assessed by positive and negative symptom scale (PANSS). Results The level of serum VEGF was significantly lower in patients group than in healthy control group [medians (lower and upper quartiles) were 3.77 (2.61, 5.14) pg/mL vs. 6.21 (4.37, 11.16) pg/mL, P<0.01]. There was no significant difference in serum VEGF levels between patients with different gender, smoking or family history of mental illness (P>0.05). The level of VEGF was negatively correlated with the total score of PANSS (r=-0.27, P=0.03), negative symptom subscale score (r=-0.25, P=0.04), lack of response score (r=-0.26, P=0.02), but not with other PANSS scores (P>0.05). Conclusion The serum level of VEGF in patients with stable schizophrenia is lower than that in healthy control group. There is, to some degree, a relationship between the level of VEGF and the severity of clinical symptoms in patients with stable schizophrenia.
作者
贾强
冯薇
谭淑平
李佳
王志仁
杨甫德
田莉
谭云龙
JIA Qiang;FENG Wei;TAN Shuping;LI Jia;WANG Zhiren;YANG Fude;TIAN Li;TAN Yunlong(Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2019年第6期346-350,共5页
Chinese Journal of Nervous and Mental Diseases
基金
北京市医管局临床技术创新项目(编号:XMLX201513)
国家自然科学基金国际(地区)合作项目(中芬)(编号:81461130016)
关键词
精神分裂症
临床症状
血管内皮生长因子
Schizophrenia
Clinical symptoms
Vascular endothelial growth factor
作者简介
通信作者:谭云龙,(E-mail:yltan21@126.com).
