摘要
目的探讨高压氧辅助治疗对改善原发性肝癌患者肝动脉化疗栓塞术(TACE)后不良反应及生活质量的作用。方法便利选取2020年1月至2021年12月于新乡市中心医院行TACE治疗的94例原发性肝癌患者为研究对象, 将患者随机分为观察组和对照组各47例, 对照组患者TACE术后予以物理降温、护肝、液体支持等对症处理, 观察组在对照组基础上行高压氧辅助治疗, 比较2组患者发热、腹痛、腹胀、恶心呕吐等不良反应发生情况, 以及手术前后的肝功能指标、血常规指标和生活质量(Karnofsky功能状态评分)状况。结果 2组患者发热、腹痛、腹胀及恶心呕吐的发生率差异无统计学意义(P>0.05), 但观察组患者腹痛和腹胀平均天数少于对照组, 差异有统计学意义(P<0.05)。术前2组患者丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、红细胞(RBC)、白细胞(WBC)、血小板(PLT)及Karnofsky功能状态评分差异无统计学意义(P>0.05);术后3、7、14 d, 观察组患者ALT及AST低于对照组, RBC、WBC和PLT水平高于对照组, Karnofsky功能状态评分高于对照组, 差异均有统计学意义(P<0.05)。结论 TACE配合高压氧辅助治疗, 可减轻原发性肝癌患者腹痛、腹胀、肝功能损伤和骨髓抑制等不良反应, 提高患者生活质量。
Objective To explore the effect of hyperbaric oxygen therapy on improving adverse reactions and quality of life in patients with primary liver cancer treated with transcatheter arterial chemoembolization(TACE).Methods A total of 94 patients with primary liver cancer who received TACE in Xinxiang Central Hospital from January 2020 to December 2021 were selected as the study subjects and were divided into observation group(n=47)and control group(n=47)by the random number table method.The patients in the control group were given physical cooling,liver protection,fluid support,and other symptomatic treatments after TACE,whereas the patients in the observation group were treated with hyperbaric oxygen on the basis of the treatment of the control group.The incidences of adverse reactions such as fever,abdominal pain,abdominal distension,nausea and vomiting,liver function damage,and bone marrow suppression were analyzed and compared between the two groups,and the quality of life(Karnofsky Performance Status score)before and after surgery was compared between the two groups.Results During hospital stay,the average numbers of day of abdominal pain and abdominal distension in the observation group were significantly smaller than those in the control group with statistical differences(P<0.05).There was no significant difference in alanine aminotransferase(ALT),aspartate aminotransferase(AST),red blood cell(RBC),white blood cell(WBC),and platelet(PLT)levels,and Karnofsky Performance Status score between the two groups before surgery(P>0.05).Three,seven,and fourteen days after surgery,ALT and AST levels in the observation group were lower than those in the control group;whereas RBC,WBC,and PLT levels,and Karnofsky Performance Status score in the observation group were higher than those in the control group,all with statistically significant differences(P<0.05).Conclusion Hyperbaric oxygen therapy combined with TACE in patients with primary liver cancer can reduce abdominal pain,abdominal distension,liver function damage,and bone marrow suppression and improve the quality of life of patients.
作者
张龙
王海溥
沈裕厚
尹宏达
琚安栋
郭俊强
岳爱民
Zhang Long;Wang Haipu;Shen Yuhou;Yin Hongda;Ju Andong;Guo Junqiang;Yue Aimin(Department of Surgical Oncology,Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College,Xinxiang 453000,China)
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2023年第6期750-754,共5页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
关键词
高压氧
肝动脉化疗栓塞术
原发性肝癌
不良反应
生活质量
Hyperbaric oxygen
Transcatheter arterial chemoembolization
Primary liver cancer
Adverse reaction
Quality of life
作者简介
通信作者:岳爱民,Email:xxchyam@163.com。
