摘要
目的:探讨加味逍遥散联合解毒疏肝汤在肝郁脾虚型原发性肝癌(PLC)介入术后综合症中的治疗价值,分析其对患者肝功能、血清肝癌特异性甲胎蛋白(HS-AFP)的影响。方法:选取2018年2月~2020年2月沧州市传染病医院收治的肝郁脾虚型PLC肝动脉栓塞化疗术(TACE)后综合征患者102例,随机数字表法分成观察组和对照组,各51例。对照组给予常规对症处理,观察组在对照组基础上给予加味逍遥散联合解毒疏肝汤治疗。比较两组治疗效果以及治疗前后的中医证候积分,分别在治疗前后检测两组肝功能指标,包括总胆红素(TBil)、谷氨酰转移酶(γ-GT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、谷丙转氨酶(ALT)水平,与此同时,检测并比较两组血清HS-AFP表达的变化,记录两组TACE所致毒副反应发生率。结果:观察组总有效率为94.12%,高于对照组的80.39%(P<0.05)。两组治疗后中医证候积分及血清TBil、γ-GT、AST、ALP、ALT均低于治疗前,且观察组中医证候积分及血清TBil、γ-GT、AST、ALT低于对照组(P<0.05)。观察组治疗后的血清HS-AFP阳性率为33.33%,显著低于对照组的54.90%(P<0.05)。观察组(25.49%)毒副反应发生率与对照组(31.37%)比较无差异(P>0.05)。结论:加味逍遥散联合解毒疏肝汤能更有效改善肝郁脾虚型PLC介入术后综合症患者的中医症状与肝功能,降低HS-AFP阳性率,提升总体疗效,且未增加TACE术后毒副反应发生率。
Objective:To explore the therapeutic value of Jiawei Xiaoyao powder combined with Jiedu Shugan decoction in the treatment of primary liver cancer(PLC)post-intervention syndrome with liver depression and spleen deficiency,and analyze its effect on patients’liver function and serum hepatoma-specific alpha-fetoprotein(HS-AFP).Methods:A total of 102 patients with PLC syndrome after hepatic artery embolization chemotherapy(TACE)of liver depression and spleen deficiency type admitted to our hospital from February 2018 to February 2020 were selected.According to the random number table method,they were divided into Chinese medicine group and control group with 51 cases each.The control group was given routine symptomatic treatment,and the Chinese medicine group was given Jiawei Xiaoyao powder combined with Jiedu Shugan decoction on this basis.The treatment effect and the scores of TCM syndromes before and after treatment were compared between the two groups.The liver function indexes of the two groups were tested before and after treatment,including total bilirubin(TBil),glutamyltransferase(γ-GT),and aspartate aminotransferase(AST).,Alkaline phosphatase(ALP),alanine aminotransferase(ALT)levels,At the same time,the changes in the expression of serum HS-AFP in the two groups were detected and compared,and the incidence of side effects caused by TACE in the two groups was recorded.Results:The total effective rate of the Chinese medicine group is 94.12%,which is higher than 80.39%of the control group(P<0.05).After treatment,the TCM syndrome scores and serum TBil,γ-GT,AST,ALP,and ALT of the two groups were lower than before treatment,and the TCM syndrome scores and serum TBil,γ-GT,AST,ALT of the TCM group were lower than those of the control group(P<0.05).The positive rate of serum HS-AFP after treatment in the traditional Chinese medicine group was 33.33%,which was significantly lower than 54.90%in the control group(P<0.05).The incidence of side effects in the traditional Chinese medicine group(25.49%)was not different from that in the control group(31.37%)(P>0.05).Conclusion:Jiawei Xiaoyao powder combined with Jiedu Shugan decoction can more effectively improve the TCM symptoms and liver function of patients with liver depression and spleen deficiency syndrome after PLC intervention,reduce the positive rate of HS-AFP,improve the overall curative effect,and do not increase the incidence of toxic and side effects after TACE.
作者
李海霞
杨元磊
曹玉娟
孙韬
艾春健
Li Haixia;Yang Yuanlei;Cao Yujuan;Sun Tao;Ai Chunjian(Department of radiology,Cangzhou infectious disease hospital,Cangzhou 061001,Hebei province,China)
出处
《四川中医》
2022年第2期156-160,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
河北省中医药管理局科研计划项目(课题编号:2020527)
关键词
原发性肝癌
介入术后综合症
加味逍遥散
解毒疏肝汤
肝郁脾虚型
肝功能
肝癌特异性甲胎蛋白
Primary liver cancer
Post-intervention syndrome
Jiawei Xiaoyao powder
Jiedu Shugan decoction
Liver depression and spleen deficiency
Liver function
Hepatoma-specific alpha-fetoprotein
作者简介
李海霞,本科,副主任医师,主要从事放射介入研究,E-mail:superpowers_88@163.com。
