摘要
目的探讨高压氧联合早期认知功能训练对一氧化碳(CO)中毒迟发型脑病患者神经功能及认知损伤的影响.方法选取该院2020年6月—2022年9月收治的96例CO中毒迟发型脑病患者为研究对象,按照随机数字表法分为对照组(n=48)和观察组(n=48).两组患者均接受常规治疗,在此基础上,对照组患者采用早期认知功能训练,观察组患者于对照组基础上加用高压氧.两组均治疗30 d.观察并比较两组患者的临床疗效、治疗前和治疗后的神经功能、认知功能、日常生活活动能力.结果观察组治疗总有效率为89.58%,高于对照组的56.25%,差异有统计学意义(P<0.05).治疗前,两组患者美国国立卫生研究院卒中量表(NIHSS)评分、简易智力状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、改良Barthel指数评定量表(MBI)评分相比,组间差异无统计学意义(P>0.05);治疗后,观察组患者NIHSS评分(5.54±1.01)分低于对照组的(3.28±2.07)分,MMSE评分(24.31±3.92)分、MoCA评分(25.56±3.69)分、MBI评分(69.71±6.26)分均高于对照组的(19.22±4.36)分、(20.02±2.48)分、(47.25±5.83)分,组间差异有统计学意义(P<0.05).结论采用高压氧联合早期认知功能训练治疗CO中毒迟发型脑病患者具有显著的临床效果,能够明显改善患者的神经功能,减轻认知功能损伤程度,促进日常生活活动能力提升.
Objective To explore the effect of hyperbaric oxygen combined with early cognitive function training on neurological function and cognitive impairment in patients with delayed encephalopathy of carbon monoxide(CO)poisoning.Methods 96 patients with delayed encephalopathy of CO poisoning from June 2020 to September 2022 were selected as the study objects,which were divided into a control group(n=48)and an observation group(n=48)according to the random number method.Both groups received conventional treatment.On the basis of this,the control group received early cognitive function training,and the observation group received hyperbaric oxygen on the basis of the control group.Both groups were treated for 30 days.The clinical efficacy,neurological function,cognitive function and daily living ability before and after treatment of the two groups were observed and compared.Results The total effective rate of the observation group was 89.58%,which was higher than 56.25%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in National Institute of Health stroke scale(NIHSS)score,mini-mental state examination(MMSE)score,Montreal cognitive assessment(MoCA)score and modified Barthel index(MBI)score between the two groups(P>0.05);after treatment,the NIHSS score of the observation group was(5.54±1.01)points,which was lower than(3.28±2.07)points of the control group,the MMSE score,MoCA score and MBI score of the observation group were(24.31±3.92)points,(25.56±3.69)points and(69.71±6.26)points,respectively,which were higher than(19.22±4.36)points,(20.02±2.48)points and(47.25±5.83)points of the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion The use of hyperbaric oxygen combined with early cognitive function training in the treatment of patients with delayed encephalopathy of CO poisoning has significant clinical effects,which can significantly improve the neurological function of patients,reduce the degree of cognitive function injury,and promote the improvement of the ability of daily living activities.
作者
张光民
ZHANG Guangmin(Department of Emergency,Guangrao County People's Hospital,Dongying Shandong,257300,China)
出处
《反射疗法与康复医学》
2023年第8期175-178,共4页
Reflexology And Rehabilitation Medicine
关键词
CO中毒迟发型脑病
高压氧
早期认知功能训练
神经功能
认知损伤
Delayed encephalopathy of CO poisoning
Hyperbaric oxygen
Early cognitive function training
Neurological function
Cognitive impairment
作者简介
张光民(1977-),男,山东东营人,本科,主治医师,研究方向:急诊与重症医学。
