摘要
目的探究火针放血联合自拟除湿消痤汤治疗马拉色菌毛囊炎的疗效及作用机理。方法按标准筛选符合的病例随机分为对照组(自拟除湿消痤汤治疗)和治疗组(自拟除湿消痤汤联合火针放血治疗),记录2组治疗前后症状及皮损变化评分、真菌检查、不良反应等指标。结果经治疗后,治疗组的显效率为88.89%,对照组的显效率为65.38%,组间疗效结果对比有显著性差异(P<0.05)。2组自觉症状明显改善,组内对比均有显著性差异(P<0.01),组间对比治疗组的改善情况优于对照组(P<0.05)。治疗组与对照组真菌清除率组内对比有显著性差异(P<0.05)。治疗组与对照组均无出现明显皮肤局部反应及可能出现的其他不良反应(P>0.05)。结论火针放血联合除湿消痤汤治疗马拉色菌毛囊炎的疗效显著,且能抑制真菌感染,无明显不良反应,安全性高,其作用机制可能与局部皮肤炎症水平下降及微循环改善等相关。
Objective To explore the therapeutic effect and mechanism of fire needle bloodletting therapy combined with self-made Chushi Xiaocuo decoction in the treatment of Malassezia folliculitis.Methods According to the criteria,the eligible cases were randomly selected and divided into a control group(treated with self-made Chushi Xiaocuo decoction)and a treatment group(treated with self-made Chushi Xiaocuo decoction combined withfire needle bloodletting).The symptoms and skin lesion scores,fungal examination,adverse reactions,and other indicators were recorded before and after treatment in both groups.Results After treatment,the marked effective rate of the treatment group was 88.89%,while the marked effective rate of the control group was 65.38%,with a significant difference between them(P<0.05).The self-conscious symptoms were significantly improved in the two groups(P<0.01),and there was a significant difference between the two groups(P<0.01).There was a significant difference in fungal clearance rate between the two groups(P<0.05).There were no significant local skin reactions or other possible adverse reactions in the two groups(P>0.05).Conclusion The combination of fire needle bloodletting and Chushi Xiaocuo decoction is effective in the treatment of Malassezia folliculitis,which can inhibit fungal infection,with no significant adverse reactions and a high safety.Its mechanism may be related to a decrease in local skin inflammation and an improvement in microcirculation.
作者
蒋丽媛
蔡玲玲
张丰川
李元文
孙铭梓
聂颖
周红梅
张馨月
刘恩知
JIANG Liyuan;CAI Lingling;ZHANG Fengchuan;LI Yuanwen;SUN Mingzi;NIE Ying;ZHOU Hongmei;ZHANG Xinyue;LIU Enzhi(Beijing University of Chinese Medicine,Beijing 100029,China;Oriental Hospital of Beijing University of Chinese Medicine,Beijing 100078,China;The First Affiliated Hospital of Guizhou University of Chinese Medicine,Guiyang 550001,China)
出处
《吉林中医药》
2024年第1期106-110,共5页
Jilin Journal of Chinese Medicine
基金
2022年度北京中医药“十四五”重点专科项目(BJZKBC0015)。
关键词
马拉色菌毛囊炎
火针
放血
作用机理
Malassezia folliculitis
fire needle
bloodletting therapy
mechanism of action
作者简介
蒋丽媛(1995-),女,硕士研究生,主要从事中医皮肤病研究;通信作者:蔡玲玲,电子信箱-cai4420450@163.com。
