摘要
目的:观察脑心通胶囊联合重组人组织型纤溶酶原激活物(rt-PA)静脉溶栓治疗卒中患者的效果。方法:选取2021年3月至2022年12月该院收治的110例卒中患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各55例。对照组采用rt-PA静脉溶栓治疗,研究组在对照组基础上联合脑心通胶囊治疗。比较两组临床疗效、治疗前后微循环指标[最大峰值时间(TTP)、平均通过时间(MTT)、局部脑血流量(rCBF)、局部脑血容量(rCBV)]水平、肢体运动功能[步行能力、简化Fugl-Meyer运动功能量表(FMA)]评分、氧化应激指标[过氧化脂质(LPO)、超氧化物歧化酶(SOD)、丙二醛(MDA)]水平、神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]评分和日常生活能力[Barthel指数(BI)评定量表]评分。结果:研究组治疗总有效率为90.91%,高于对照组的76.36%,差异有统计学意义(P<0.05);治疗后,研究组rCBV、rCBF水平均高于对照组,TTP、MTT水平均低于对照组,差异有统计学意义(P<0.05);研究组上肢运动评分、下肢运动评分均高于对照组,步行能力评分低于对照组,差异有统计学意义(P<0.05);研究组SOD水平高于对照组,LPO、MDA水平均低于对照组,差异有统计学意义(P<0.05);研究组BI评分高于对照组,NIHSS评分低于对照组,差异有统计学意义(P<0.05)。结论:脑心通胶囊联合rt-PA静脉溶栓治疗卒中患者,可提高临床疗效和肢体功能,改善微循环,减轻机体氧化应激反应和神经功能缺损,提高日常生活能力,其效果优于单纯rt-PA静脉溶栓治疗。
Objective:To observe effects of Naoxintong capsules combined with recombinant human tissue plasminogen activator(rt-PA)intravenous thrombolysis in treatment of stroke patients.Methods:A prospective study was conducted on 110 stroke patients admitted to the hospital from March 2021 to December 2022.They were divided into control group and study group according to the random number table method,55 cases in each.The control group was treated with rt-PA intravenous thrombolysis,while the study group was treated with Naoxintong capsules on the basis of that of the control group.The clinical efficacy,the microcirculation index levels[maximum peak time(TTP),mean transit time(MTT),regional cerebral blood flow(rCBF),regional cerebral blood volume(rCBV)],the limb movement function index levels[walking ability score,simplified Fugl-Meyer assessment(FMA)],the oxidative stress index levels[lipid peroxide(LPO),superoxide dismutase(SOD),malondialdehyde(MDA)],the neurological deficit degree[National Institutes of Health stroke scale(NIHSS)],and the daily living ability[Barthel index(BI)rating scale]were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 90.91%,which was higher than 76.36%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of rCBV and rCBF in the study group were higher than those in the control group,the levels of TTP and MTT were lower than those in the control group,and the differences were statistically significant(P<0.05).The upper limb movement score and the lower limb movement score of the study group were higher than those of the control group,the walking ability score was lower than that of the control group,and the differences were statistically significant(P<0.05).The level of SOD in the study group was higher than that in the control group,the levels of LPO and MDA were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the BI score of the study group was higher than that of the control group,the NIHSS score was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusions:Naoxintong capsules combined with rt-PA intravenous thrombolysis in the treatment of the stroke patients can improve the clinical efficacy and the limb function,improve the microcirculation,reduce the oxidative stress response and the neurological deficits,and improve the daily living ability.Moreover,it is superior to single simple rt-PA intravenous thrombolytic therapy.
作者
郭文彬
GUO Wenbin(Department of Neurology of Wugang People’s Hospital,Wugang 462500 Henan,China)
出处
《中国民康医学》
2023年第16期93-96,共4页
Medical Journal of Chinese People’s Health
关键词
脑心通胶囊
RT-PA静脉溶栓
卒中
肢体运动
氧化应激
Naoxintong capsules
rt-PA intravenous thrombolysis
Stroke
Limb movement
Oxidative stress
作者简介
郭文彬(1989.12-),女,汉族,河南舞钢人,本科,主治医师,研究方向为神经病学。
