摘要
目的本研究评估儿童和青少年抑郁症(MDD)患者系统免疫-炎症指数(SII)与自杀意念的相关性。方法本回顾性研究纳入在阜阳市三院住院治疗的795名患有MDD的儿童和青少年。依据有无自杀意念进行分组,比较两组患者SII和临床病理特征的差异,使用受试者操作特征曲线(ROC)测定SII的最佳临界值和曲线下面积,使用二元Logistic回归分析自杀意念的独立危险因素。结果与无自杀意念的患者相比,伴有自杀意念的MDD患者的汉密尔顿抑郁量表评分,中性粒细胞和SII水平更高(P均<0.001)。最佳临界SII值是310.95(敏感=73.7%,特异性=44.7%),曲线下面积为0.603。在Logistic回归模型中,在控制年龄、性别、发病年龄、病程和汉密尔顿抑郁量表评分后,SII与自杀意念显著相关(β=0.809,P<0.001;OR[95%置信区间]=2.246[1.543~3.270])。结论SII是影响儿童和青少年MDD患者自杀意念的独立危险因素。
Objective The aim of this study was to assess the correlation between systemic immune-inflammato-ry index(SII)and suicidal ideation in children and adolescents with depression(MDD).Methods This retrospective study included 795 children and adolescents with MDD who were hospitalized in Third people's hospitals of Fuyang.Patients were grouped according to the presence or absence of suicidal ideation,and the differences in SII and clinico-pathological characteristics between the two groups were compared.The optimal critical value of SII and the area under the curve were determined using the subject operating characteristic curve(ROC),and independent risk factors for suicidal ideation were analyzed using binary Logistic regression.Results Patients with MDD with suicidal ideation had higher Hamilton Depression Scale scores,neutrophil,and SII levels compared to those without suicidal ideation(all P<0.001).The optimal critical SII value was 310.95(sensitivity=73.7%,specificity=44.7%)with an area under the curve of 0.603.In a Logistic regression model,SII was significantly associated with suicidal ideation after controlling for age,sex,age at onset,duration of llness,and Hamilton Depression Scale score(β=0.809,P<0.001,OR[95%confidence interval]=2.246[1.543~3.270]).Conclusion SII is an independent risk factor affecting suicidal ideation in children and adolescents with MDD.
作者
崔舒
刘志伟
刘云
姚高峰
孙锋
孙龙龙
CUI Shu;LIU Zhiwei;LIU Yun(Third People's Hospital of Fuyang,Fuyang 236000,China)
出处
《国际精神病学杂志》
2023年第4期699-702,共4页
Journal Of International Psychiatry
基金
安徽省阜阳市卫生健康委科研课题(编号:FY2020xg14)。
关键词
抑郁障碍
自杀意念
儿童和青少年
系统性免疫炎性指数
Major depressive disorder
Suicidal ideation
Children and adolescents
Systemic immune-inflam-mationindex
作者简介
第一作者:崔舒(1987.10-),女,安徽阜阳人,硕士研究生,主治医师,中级心理治疗师,研究方向:临床精神医;通讯作者:刘云,Email:psyah@126.com。
