摘要
目的分析乙肝肝硬化患者血清白细胞介素-21、γ-干扰素、骨桥蛋白水平变化及其与抑郁情绪的关系。方法将69例乙肝肝硬化患者设为肝硬化组、71例乙肝无肝硬化患者设为无肝硬化组。检测两组患者血清白细胞介素-21、γ-干扰素和骨桥蛋白水平,采用抑郁自评量表评估两组患者抑郁情绪,分析肝硬化组患者血清白细胞介素-21、γ-干扰素和骨桥蛋白水平及其与抑郁情绪的关系。结果肝硬化组患者血清白细胞介素-21、γ-干扰素、骨桥蛋白水平及抑郁指数均高于无肝硬化组,差异有统计学意义(P<0.01)。69例乙肝肝硬化患者中,39例抑郁指数≥0.50,其中轻度抑郁13例、中度抑郁21例、重度抑郁5例。轻度、中度和重度肝硬化患者血清白细胞介素-21、γ-干扰素、骨桥蛋白水平及抑郁指数均逐渐增高,差异有统计学意义(P<0.01)。进一步分析,组间两两比较差异有统计学意义(P<0.01)。抑郁指数≥0.50的患者血清白细胞介素-21、γ-干扰素、骨桥蛋白水平均高于抑郁指数<0.50患者,差异有统计学意义(P<0.01)。Logistic回归分析提示血清白细胞介素-21、γ-干扰素和骨桥蛋白水平均是乙肝肝硬化患者抑郁情绪的独立影响因素(P<0.01)。Pearson相关分析显示乙肝肝硬化患者血清白细胞介素-21、γ-干扰素和骨桥蛋白水平与抑郁指数呈正相关(P<0.01)。结论乙肝肝硬化患者存在明显抑郁情绪,其病情程度和抑郁情绪均与血清白细胞介素-21、γ-干扰素和骨桥蛋白水平密切相关,重视患者抑郁情绪防治及血清白细胞介素-21、γ-干扰素和骨桥蛋白水平监测,对患者病情控制和预后改善有重要意义。
Objective To analyze the relationship of serum interleukin-21(IL-21),interferon-gamma(IFN-γ)and osteopontin(OPN)levels with depressive emotions in patients with hepatitis B cirrhosis.Methods Sixty-nine patients with hepatitis B cirrhosis were assigned to cirrhosis group and 71 hepatitis B ones without cirrhosis to non-cirrhosis group.Serum IL-21,IFN-γand OPN levels were detected in two groups,depressive emotions assessed with the Self-rating Depression Scale(SDS),and serum IL-21,IFN-γand OPN levels in cirrhosis group and their relationship with depressive emotions analyzed.Serum IL-21,IFN-γand OPN levels in patients with hepatitis B cirrhosis,and their relationship with depression were analyzed.Results Serum IL-21,IFN-γand OPN levels and depression index were all higher in cirrhosis than non-cirrhosis group,differences were statistically significant(P<0.01).In cirrhosis group depression indexes of 39 patients were≥0.50,among them,13 cases mild depression,21 moderate,and 5 severe.Serum IL-21,IFN-γand OPN levels and depression indexes gradually elevated in mild,moderate and severe cirrhosis patients,differences were statistically significant(P<0.01).Further analyses showed that intergroup pairwise comparison differences were statistically significant(P<0.01).Serum IL-21,-IFN-γand OPN levels were higher in patients with depression indexes≥0.5 than ones<0.5,differences were statistically significant(P<0.01).Logistic regression analysis showed that serum IL-21,IFN-γand OPN level were independent influencing factor of depressive emotions(P<0.01).Pearson correlation analysis showed that serum IL-21,IFN-γand OPN level were positively related to depression index of hepatitis B cirrhosis patients(P<0.01).Conclusion Hepatitis B cirrhosis patients have obvious depressive emotions,their illness degrees and depressive emotions are closely related to serum IL-21,IFN-γand OPN levels,and it is of great significance for disease control and prognosis improvement to pay attention to the prophylaxis and treatment of depressive emotions and the monitoring of serum IL-21,IFN-γand OPN levels.
作者
文正燕
孙传俊
李振玉
Wen Zhengyan;Sun Chuanjun;Li Zhenyu(Xinxiang Hospital for Infectious Diseases,Xinxiang 453000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2023年第5期18-22,共5页
Journal of Clinical Psychosomatic Diseases
基金
河南省重点科技攻关项目(编号LHGJ20210901)。
作者简介
文正燕,女,46岁,汉族,硕士,高级职称。主要研究成果:发表专业论文4篇。研究方向:肝脏损伤修复与再生机制;通讯作者:李振玉,硕士研究生导师(Email:lizhenyu637@163.com)。
