摘要
目的:探讨治疗前系统免疫炎症指数(SII)、纤维蛋白原/白蛋白比值(FAR)对晚期肺癌一线含铂化疗患者预后的预测价值。方法:回顾性分析2017年1月至2021年12月本院收治的260例晚期肺癌患者的临床资料。绘制受试者工作特征(ROC)曲线,确定SII、FAR的截断值,分别以SII、FAR截断值将患者分为高水平组与低水平组,分析不同SII、FAR表达水平的晚期肺癌患者临床病理特征及总生存期,对影响晚期肺癌患者预后的因素进行单因素和多因素Cox回归分析。结果:260例患者中位生存时间为18个月,死亡172例(66.15%),生存88例(33.85%)。SII、FAR、SII-FAR预测晚期肺癌患者预后的ROC曲线下面积(AUC)分别为0.730、0.656、0.733,灵敏度分别为0.616、0.761、0.622,特异度分别为0.750、0.669、0.705。SII高水平组与SII低水平组患者肿瘤直径、胸腔积液情况比较,差异有统计学意义(P<0.05)。FAR高水平组与FAR低水平组患者性别、年龄、吸烟史、病理类型、肿瘤直径、治疗方案对比,差异有统计学意义(P<0.05)。SII低水平组存活率高于SII高水平组,FAR低水平组存活率高于FAR高水平组(均P<0.05)。高水平SII是影响晚期肺癌患者预后的独立危险因素(P<0.05)。SII与FAR呈正相关关系(r=0.412,P<0.001)。结论:治疗前SII、FAR水平对晚期肺癌患者预后有一定的预测价值,SII、FAR低水平的晚期肺癌患者生存预后情况优于SII、FAR高水平患者。
Objective:To explore the predictive value of systemic immune inflammation index(SII)and fibrinogen/albumin ratio(FAR)on the prognosis of patients with advanced lung cancer undergoing first-line platinumcontaining chemotherapy before treatment.Methods:The clinical data of 260 patients with advanced lung cancer admitted to our hospital from January 2017 to December 2021 were analyzed retrospectively.The cut-off values of SII and FAR were determined by drawing the receiver operating characteristic(ROC)curve,and the patients were divided into high level group and low level group by the cut-off values of SII and FAR.The clinicopathological characteristics and total survival time of patients with advanced lung cancer with different SII and FAR expression levels were analyzed,and the factors affecting the prognosis of patients with advanced lung cancer were analyzed by univariate and multivariate Cox regression analysis.Results:The median survival time of 260 patients was 18 months,172 patients died(66.15%)and 88 patients survived(33.85%).The areas under ROC curve(AUC)of SII,FAR and SII-FAR for predicting the prognosis of patients with advanced lung cancer were 0.730,0.656 and 0.733,respectively.The sensitivity and the specificity were 0.616 and 0.761,0.622 and 0.750,and 0.669 and 0.705,respectively.The tumor diameter and pleural effusion of patients in the high SII level group and low SII level group were significantly different(P<0.05).There were significant differences(P<0.05)in sex,age,smoking history,pathological type,tumor diameter,and treatment regimen between patients in the high FAR level group and those in the low FAR level group.The survival rate of patients in the low SII level group was higher than that in the high SII level group,and the survival rate of patients in the low FAR level group was higher than that in the high FAR level group(all P<0.05).High level of SII was an independent risk factor affecting the prognosis of patients with advanced lung cancer(P<0.05)and there was a positive correlation between SII and FAR(r=0.412,P<0.001).Conclusion:The levels of SII and FAR before treatment have certain predictive value for the prognosis of advanced lung cancer patients.Patients with low levels of SII and FAR have better survival prognosis than those with high levels of SII and FAR.
作者
黄琴
蒿艳蓉
吕艳茹
谢嫣嫣
兰海燕
徐志勇
高珊
农向阳
张凌宇
麦洪华
Huang Qin;Hao Yanrong;Lyu Yanru;Xie Yanyan;Lan Haiyan;Xu Zhiyong;Gao Shan;Nong Xiangyang;Zhang Lingyu;Mai Honghua(Youjiang Medical University for Nationalities,Baise 533000,China;Department of Oncology,People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Department of Oncology,Yulin Red Cross Hospital,Yulin 537000,China;Department of Respiratory and Critical Care Medicine,People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)
出处
《广西医科大学学报》
CAS
2023年第8期1321-1328,共8页
Journal of Guangxi Medical University
基金
广西重点研发计划资助项目(No.桂科AB21196012)
广西壮族自治区卫生健康委员会自筹经费科研课题资助项目(No.Z20201140)。
作者简介
通信作者:蒿艳蓉,E-mail:yanronghao.2008@yahoo.com.cn。
