摘要
目的探讨能谱CT和血清HE4对化疗及靶向治疗晚期肺癌的疗效评价。方法分析2020年3月—2022年2月在唐山市人民医院进行化疗或靶向治疗并在治疗前后行能谱CT和血清HE4水平检测的80例晚期肺癌患者作为研究对象,根据治疗方式的不同将其分为化疗组(n=40)和靶向治疗组(n=40)。观察比较二组的临床疗效、治疗前后能谱CT参数和血清HE4水平、KPS评分和不良反应发生情况。结果靶向治疗组客观缓解率(ORR)和疾病控制率(DCR)高于化疗组(P<0.05);治疗前二组能谱CT参数和血清HE4水平无差异(P>0.05),治疗后靶向治疗组动脉期IC、静脉期IC、动脉期WC、静脉期WC、动脉期CT70ke V、静脉期CT70ke V、动脉期λHU、静脉期λHU及血清HE4水平均低于化疗组(P<0.05);治疗前二组KPS评分比较差异无统计学意义(P>0.05),治疗后,化疗组和靶向治疗组KPS评分均显著提高,靶向治疗组KPS评分高于化疗组(P<0.05);靶向治疗组出现转氨酶升高、皮疹、腹泻风险高于化疗组,化疗组出现白细胞减少、血小板减少、贫血、肌酐升高、血尿及蛋白尿风险高于靶向治疗组,食欲下降及关节痛出现风险二组相仿。相比于化疗组,靶向治疗组出现白细胞减少、血小板减少均明显减少(P<0.05)。结论靶向治疗晚期肺癌相比较传统化疗的临床治疗效果显著,可降低能谱CT参数和血清HE4水平,不良反应发生率低,安全性高。
Objective To evaluate the efficacy of energy spectrum CT and serum HE4 in chemotherapy and targeted treatment of advanced lung cancer.Methods Analysis was made on eighty patients with advanced lung cancer who were treated with chemotherapy or targeted therapy in Tangshan People's Hospital from March 2020 to February 2022,and were tested with energy spectrum CT and serum HE4 levels before and after treatment.They were divided into chemotherapy group(n=40)and targeted treatment group(n=40)according to different treatment methods.The clinical efficacy,energy spectrum CT parameters,serum HE4 level,KPS score and adverse reactions of the two groups were observed and compared before and after treatment.Results The objective response rate(ORR)and disease control rate(DCR)of the targeted treatment group were higher than those of the chemotherapy group(P<0.05);There was no difference in the energy spectrum CT parameters and serum HE4 levels between the two groups before treatment(P>0.05).After treatment,the target treatment group targeted the arterial phase IC,venous phase IC,arterial phase WC,venous phase WC,arterial phase CT 70keV,venous phase CT 70keV,arterial phase^HU,venous phase^HU The levels of HU and serum HE4 were significantly lower than those of chemotherapy group(P<0.05).Before treatment,the KPS scores of the two groups were not statistically significant(P>0.05).After treatment,the KPS scores of the chemotherapy group and the targeted treatment group were significantly improved.The KPS scores of the targeted treatment group were higher than those of the chemotherapy group,and the comparison between the two groups was statistically significant(P<0.05);The risk of increased transaminase,rash and diarrhea in the targeted treatment group was higher than that in the chemotherapy group.The risk of leukopenia,thrombocytopenia,anemia,creatinine increase,hematuria and proteinuria in the chemotherapy group was higher than that in the targeted treatment group.The risk of decreased appetite and arthralgia in the two groups was similar.Compared with the chemotherapy group,leukopenia and thrombocytopenia in the targeted treatment group were significantly reduced,and the difference was statistically significant(P<0.05).Conclusion Compared with traditional chemotherapy,targeted treatment of advanced lung cancer has a significant clinical effect.It can reduce the parameters of energy spectrum CT and the level of serum HE4.The incidence of adverse reactions is low and the safety is high.
作者
李玉柱
陈大鹏
肖建波
张玉敏
张小楠
刘启为
缐丽歌
LI Yuzhu;CHEN Dapeng;XIAO Jianbo;ZHANG Yumin;LI Anping;WANG Ying(Department of Radiology,Tangshan People's Hospital,Tangshan 063000,China)
出处
《中国煤炭工业医学杂志》
2023年第3期252-256,共5页
Chinese Journal of Coal Industry Medicine
基金
2022年度河北省医学科学研究重点课题(编号:20220218)。
关键词
肺癌
化疗
靶向治疗
能谱CT
HE4
Lung cancer
Chemotherapy
Target therapy
Energy spectrum CT
HE4
作者简介
通讯作者:张玉敏。
